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SIFT BLink specifications


Unique identifier OMICS_26256
Name SIFT BLink
Interface Web user interface
Restrictions to use None
Input data A protein sequence, some related sequences or aligned sequences.
Input format FASTA
Computer skills Basic
Stability Stable
Maintained No


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Publication for SIFT BLink

SIFT BLink citations


Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling

PLoS One
PMCID: 5456385
PMID: 28575107
DOI: 10.1371/journal.pone.0178776
call_split See protocol

[…] he Human Gene Mutation Database (HGMD). Predictive analysis tools were used to determine the pathogenicity status of novel variants. Missense mutations were analyzed by SIFT (, CADD ( and Mutation taster (, while all frameshift variants were predicted by PROVEAN (http://provean.jcvi.o […]


Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer

Sci Rep
PMCID: 5363706
PMID: 28272408
DOI: 10.1038/srep43830

[…] NPs associated with the non-homeobox region of HOXB13 gene were predicted using the following in silico servers: The SIFT (Sorting Intolerant From Tolerant) program ( predicts the deleterious or damaging nature of the missense SNPs based upon sequence homology based prediction, physical properties of amino acids and also by calculating the d […]


A novel MTTT mutation m.15933G > A revealed in analysis of mitochondrial DNA in patients with suspected mitochondrial disease

BMC Med Genet
PMCID: 5303298
PMID: 28187756
DOI: 10.1186/s12881-017-0377-8

[…] Nonsynonymous mtDNA mutations were analysed for their pathogenic potential by using PolyPhen-2 version 2.2.2 [], SIFT BLink [], PMut [, ] and SNAP [] algorithms. Pathogenicity classes were ascertained ac […]


Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease

PMCID: 4990813
PMID: 27551684
DOI: 10.1101/mcs.a001107

[…] ld lack most of the primase domain and all of the linker and helicase domains and is unlikely to be functional. The missense variant p.R302W is predicted to be damaging by PolyPhen-2 (score 1.00) and SIFT Blink (P = 0.00). Arginine at residue 302 is conserved in virtually all mammals and arginine or similarly charged lysine is conserved in virtually all vertebrates (D). Bulky hydrophobic residues […]


Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the UK

PMCID: 4502227
PMID: 26173696
DOI: 10.1128/mBio.00622-15

[…] ade-associated strains (see  in the supplemental material). Eighteen of 27 of these SNPs were nonsynonymous changes, and 14 were predicted to affect protein structure and/or function (as predicted by SIFT Blink []). We could not determine any obvious negative or positive impact that these SNPs may have on pathogenicity, based on predicted functions of the proteins, although we cannot exclude a rol […]


Associations of Polymorphisms in WNT9B and PBX1 with Mayer Rokitansky Küster Hauser Syndrome in Chinese Han

PLoS One
PMCID: 4468103
PMID: 26075712
DOI: 10.1371/journal.pone.0130202

[…] nor allele of each variant. All P-values were two-tailed and an alpha of 0.05 was used to determine statistical significance.Sorting Intolerant From Tolerant (SIFT) (, PolyPhen-2 ( and PMut ( were used in this study to predict whether an amino acid substitution in a protein […]


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SIFT BLink institution(s)
Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia; Computational and Systems Biology Group, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
SIFT BLink funding source(s)
Supported in part by A*STAR and the Croatian Science Foundation (project no. 7353, Algorithms for Genome Sequence Analysis).

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