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SIFT BLink specifications

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Unique identifier OMICS_26256
Name SIFT BLink
Interface Web user interface
Restrictions to use None
Input data A protein sequence, some related sequences or aligned sequences.
Input format FASTA
Computer skills Basic
Stability Stable
Maintained No

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Publication for SIFT BLink

SIFT BLink citations

 (34)
library_books

Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling

2017
PLoS One
PMCID: 5456385
PMID: 28575107
DOI: 10.1371/journal.pone.0178776

[…] human gene mutation database (hgmd). predictive analysis tools were used to determine the pathogenicity status of novel variants. missense mutations were analyzed by sift (http://sift.jcvi.org/www/sift_blink_submit.html), cadd (http://cadd.gs.washington.edu/score) and mutation taster (http://www.mutationtaster.org/), while all frameshift variants were predicted by provean […]

library_books

Identification of a novel de novo ANK1 R1426* nonsense mutation in a Chinese family with hereditary spherocytosis by NGS

2017
Oncotarget
PMCID: 5722523
PMID: 29228571
DOI: 10.18632/oncotarget.18243

[…] databases []. to predict possible impact of non-synonymous variants in exons, in-silico function was predicted by several software, including sift (http://sift.jcvi.org/www/sift_blink_submit.html), mutationtaster (http://www.mutationtaster.org/), mutationassessor (http://mutationassessor.org), provean http://provean.jcvi.org/index.php and polyphen-2 […]

library_books

Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer

2017
Sci Rep
PMCID: 5363706
PMID: 28272408
DOI: 10.1038/srep43830

[…] associated with the non-homeobox region of hoxb13 gene were predicted using the following in silico servers: the sift (sorting intolerant from tolerant) program (http://sift.bii.a-star.edu.sg/www/sift_blink_submit.html) predicts the deleterious or damaging nature of the missense snps based upon sequence homology based prediction, physical properties of amino acids and also by calculating […]

library_books

A novel MTTT mutation m.15933G > A revealed in analysis of mitochondrial DNA in patients with suspected mitochondrial disease

2017
BMC Med Genet
PMCID: 5303298
PMID: 28187756
DOI: 10.1186/s12881-017-0377-8

[…] substitutions in human mitochondrial trnas []., nonsynonymous mtdna mutations were analysed for their pathogenic potential by using polyphen-2 version 2.2.2 [] http://genetics.bwh.harvard.edu/pph2/, sift blink [] http://sift.jcvi.org/www/sift_blink_submit.html, pmut [, ] http://mmb2.pcb.ub.es/pmut/ and snap [] http://rostlab.org/services/snap/ algorithms. pathogenicity classes were ascertained […]

library_books

Identification of a Solanum pennellii Chromosome 4 Fruit Flavor and Nutritional Quality Associated Metabolite QTL

2016
Front Plant Sci
PMCID: 5101573
PMID: 27881988
DOI: 10.3389/fpls.2016.01671

[…] discussion and their technical assistance., www.agilent.com , http://www.thermofisher.com , http://www.genedata.com , http://www.ebi.ac.uk/tools/msa/clustalw2/ , http://sift.jcvi.org/www/sift_blink_submit.html , http://pantherdb.org/ , the supplementary material for this article can be found online at: […]

library_books

Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease

2016
PMCID: 4990813
PMID: 27551684
DOI: 10.1101/mcs.a001107

[…] lack most of the primase domain and all of the linker and helicase domains and is unlikely to be functional. the missense variant p.r302w is predicted to be damaging by polyphen-2 (score 1.00) and sift blink (p = 0.00). arginine at residue 302 is conserved in virtually all mammals and arginine or similarly charged lysine is conserved in virtually all vertebrates (d). bulky hydrophobic residues […]


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SIFT BLink institution(s)
Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia; Computational and Systems Biology Group, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
SIFT BLink funding source(s)
Supported in part by A*STAR and the Croatian Science Foundation (project no. 7353, Algorithms for Genome Sequence Analysis).

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