SIFT BLink statistics

info info

Citations per year

Number of citations per year for the bioinformatics software tool SIFT BLink
info

Tool usage distribution map

This map represents all the scientific publications referring to SIFT BLink per scientific context
info info

Associated diseases

This word cloud represents SIFT BLink usage per disease context
info

Popular tool citations

chevron_left Variant effect prediction chevron_right
Want to access the full stats & trends on this tool?

Protocols

SIFT BLink specifications

Information


Unique identifier OMICS_26256
Name SIFT BLink
Interface Web user interface
Restrictions to use None
Input data A protein sequence, some related sequences or aligned sequences.
Input format FASTA
Computer skills Basic
Stability Stable
Maintained No

Maintainer


This tool is not available anymore.

Publication for SIFT BLink

SIFT BLink citations

 (14)
call_split

Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling

2017
PLoS One
PMCID: 5456385
PMID: 28575107
DOI: 10.1371/journal.pone.0178776
call_split See protocol

[…] he Human Gene Mutation Database (HGMD). Predictive analysis tools were used to determine the pathogenicity status of novel variants. Missense mutations were analyzed by SIFT (http://sift.jcvi.org/www/SIFT_BLink_submit.html), CADD (http://cadd.gs.washington.edu/score) and Mutation taster (http://www.mutationtaster.org/), while all frameshift variants were predicted by PROVEAN (http://provean.jcvi.o […]

library_books

Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer

2017
Sci Rep
PMCID: 5363706
PMID: 28272408
DOI: 10.1038/srep43830

[…] NPs associated with the non-homeobox region of HOXB13 gene were predicted using the following in silico servers: The SIFT (Sorting Intolerant From Tolerant) program (http://sift.bii.a-star.edu.sg/www/SIFT_BLink_submit.html) predicts the deleterious or damaging nature of the missense SNPs based upon sequence homology based prediction, physical properties of amino acids and also by calculating the d […]

library_books

A novel MTTT mutation m.15933G > A revealed in analysis of mitochondrial DNA in patients with suspected mitochondrial disease

2017
BMC Med Genet
PMCID: 5303298
PMID: 28187756
DOI: 10.1186/s12881-017-0377-8

[…] ial. Mutations are then classified as benign if the probability is less than 50%, possibly damaging if the probability is greater than 50% and probably damaging if the probability is greater than 90%.SIFT BLink and PMut algorithms are based on sequence homology. These algorithms assume that functionally important protein sequences are conserved in evolution, whereas diverse positions are unimporta […]

library_books

Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease

2016
PMCID: 4990813
PMID: 27551684
DOI: 10.1101/mcs.a001107

[…] ld lack most of the primase domain and all of the linker and helicase domains and is unlikely to be functional. The missense variant p.R302W is predicted to be damaging by PolyPhen-2 (score 1.00) and SIFT Blink (P = 0.00). Arginine at residue 302 is conserved in virtually all mammals and arginine or similarly charged lysine is conserved in virtually all vertebrates (D). Bulky hydrophobic residues […]

library_books

Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the UK

2015
MBio
PMCID: 4502227
PMID: 26173696
DOI: 10.1128/mBio.00622-15

[…] ade-associated strains (see  in the supplemental material). Eighteen of 27 of these SNPs were nonsynonymous changes, and 14 were predicted to affect protein structure and/or function (as predicted by SIFT Blink []). We could not determine any obvious negative or positive impact that these SNPs may have on pathogenicity, based on predicted functions of the proteins, although we cannot exclude a rol […]

library_books

Associations of Polymorphisms in WNT9B and PBX1 with Mayer Rokitansky Küster Hauser Syndrome in Chinese Han

2015
PLoS One
PMCID: 4468103
PMID: 26075712
DOI: 10.1371/journal.pone.0130202

[…] nor allele of each variant. All P-values were two-tailed and an alpha of 0.05 was used to determine statistical significance.Sorting Intolerant From Tolerant (SIFT) (http://sift.bii.a-star.edu.sg/www/SIFT_BLink_submit.html), PolyPhen-2 (http://genetics.bwh.harvard.edu/pph2) and PMut (http://mmb2.pcb.ub.es:8080/PMut) were used in this study to predict whether an amino acid substitution in a protein […]


Want to access the full list of citations?
SIFT BLink institution(s)
Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia; Computational and Systems Biology Group, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
SIFT BLink funding source(s)
Supported in part by A*STAR and the Croatian Science Foundation (project no. 7353, Algorithms for Genome Sequence Analysis).

SIFT BLink reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review SIFT BLink