Signal-3L statistics

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Citations per year

Number of citations per year for the bioinformatics software tool Signal-3L

Tool usage distribution map

This map represents all the scientific publications referring to Signal-3L per scientific context
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Signal-3L specifications


Unique identifier OMICS_18488
Name Signal-3L
Interface Web user interface
Restrictions to use None
Input data Some protein sequences.
Input format FASTA
Computer skills Basic
Version 2.0
Stability Stable
Maintained Yes


  • person_outline Hong-Bin Shen

Publications for Signal-3L

Signal-3L citations


Alport syndrome cold cases: Missing mutations identified by exome sequencing and functional analysis

PLoS One
PMCID: 5453569
PMID: 28570636
DOI: 10.1371/journal.pone.0178630

[…] icing Finder software (, last accessed October 2016).Signal-peptide prediction of wild-type and mutant COL4A3 amino acid sequences was performed using SignalP 4.1, PrediSi, and Signal-3L 2.0 (,,, last accessed October 2016)Potential pathogenicity of the candidate COL4 […]


Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53 dependent apoptosis

PLoS One
PMCID: 5436662
PMID: 28545143
DOI: 10.1371/journal.pone.0177199

[…] SIGNAL-BLAST [] analysis indicated that the first 19, 20 and 19 aa of the N-termini of CdtA, CdtB and CdTC, respectively are signal peptides. Both Predsi ( and Signal-3L [] ( analysis indicate that the first N-terminal 19 aa and of CdtA and CdtC, and 21 aa of CdtB are signal peptides ().Based on the signal pepti […]


Transcriptome Analysis of Mango (Mangifera indica L.) Fruit Epidermal Peel to Identify Putative Cuticle Associated Genes

Sci Rep
PMCID: 5397871
PMID: 28425468
DOI: 10.1038/srep46163

[…] mango database using BLASTX (E-value ≤ 1E-5). The Coding DNA Sequence (CDS) and deduced amino acid sequence were obtained using Open Reading Frame Finder ( Signal-3L was used to identify signal peptides and PredGPI predictor to identify glycosylphosphatidylinositol (GPI) domains. Oligonucleotide primers were designed according to Thornton and Basu and ar […]


Metabolic engineering of Ustilago trichophora TZ1 for improved malic acid production

Metab Eng Com
PMCID: 5678829
PMID: 29142828
DOI: 10.1016/j.meteno.2017.01.002

[…] 7% homology), Mdh1 (97% homology), Mdh2 (94% homology), Ssu1 (89% homology), and Ssu2 (68% homology). For the malate dehydrogenases N-terminal targeting sequences were analyzed using a combination of Signal-3L and TargetP 1.1 (). The putative localization for Mdh1 was the cytosol and for Mdh2 the mitochondrion. The N-terminal mitochondrial targeting sequence for mdh2 was either retained or removed […]


SEC Translocon Dependent Extracytoplasmic Proteins of Candidatus Liberibacter asiaticus

Front Microbiol
PMCID: 5167687
PMID: 28066334
DOI: 10.3389/fmicb.2016.01989

[…] senger protein for transportation out of the cytoplasm in prokaryotes (). Many methods have been used for predicting signal peptides, including SignalP (; ; ; ), PrediSi (), SPEPlip (), Signal-CF (), Signal-3L (), signal-BLAST (), Phobius (), LipoP () and Philius (). All the prediction methods have limited ability to discriminate between signal peptides and N-terminal transmembrane helices. The co […]


The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains

PLoS One
PMCID: 5104382
PMID: 27832149
DOI: 10.1371/journal.pone.0166274

[…] 9), Spoctopus (; cleavage at G58), SPEPLip (; cleavage at A59), Signal3L (; cleavage at A30), EMBOSS sigcleave (; cleavage at A32), and SignalP (; SPI signal sequence not f […]

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Signal-3L institution(s)
Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, China; Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China
Signal-3L funding source(s)
Supported by the Natural Science Foundation of China (NSFC Nos. 61671288, 91530321, 61603161), and Science and Technology Commission of Shanghai Municipality (No. 16JC1404300).

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