Predicts improved signal peptide. Signal-3L uses a hierarchical protocol that determines the existence of a signal peptide and then prioritizes potential cleavage sites. The tool uses statistical learning rules to select a final unique site in concertation with its evolution conservation score. The signal peptide obtained in useful to understand secretory proteins.
Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, China; Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China
Signal-3L funding source(s)
Supported by the Natural Science Foundation of China (NSFC Nos. 61671288, 91530321, 61603161), and Science and Technology Commission of Shanghai Municipality (No. 16JC1404300).