Allows to make gene expression signature analysis. SIGNATURE works with a GenePattern interface on top of a complex infrastructure of analysis software and a signature database. It contains an algorithm allowing to handle the idiosyncrasies of gene expression data. Its platform comprises two modules, Score Signatures and Create Signature, that are useful in interpreting gene expression data. It can be used to deliver complex algorithms in a user-friendly manner or putting sophisticated bioinformatic analyses.
Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston, Houston, TX, USA; Institute for Genome Sciences and Policy Duke University and Duke University Medical Center, Durham, NC, USA; Department of Biostatistics and Bioinformatics Duke University Medical Center, Durham, NC, USA; Department of Molecular Genetics and Microbiology Duke University Medical Center, Durham, NC, USA
SIGNATURE funding source(s)
Supported by NIH R00LM009837 and grant R1006 from the Cancer Prevention Research Institute of Texas, and by NIH 5R01CA106520 and NIH U54CA112952.