An online application for subgroup-free residue-level genotype-phenotype correlation. In contrast to similar methods, SigniSite does not require any pre-definition of subgroups or binary classification. Input is a set of protein sequences where each sequence has an associated real number, quantifying a given phenotype. SigniSite will then identify which amino acid residues are significantly associated with the data set phenotype. As output, SigniSite displays a sequence logo, depicting the strength of the phenotype association of each residue and a heat-map identifying 'hot' or 'cold' regions.

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SigniSite specifications

Interface:
Web user interface
Computer skills:
Basic
Restrictions to use:
None
Stability:
Stable

Publications

  • (Jessen et al., 2013) SigniSite: Identification of residue-level genotype-phenotype correlations in protein multiple sequence alignments. Nucleic acids research.
    PMID: 23761454

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