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SigniSite specifications


Unique identifier OMICS_04923
Name SigniSite
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Leon Jessen

Publication for SigniSite

SigniSite citations


Cross recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high density peptide microarray epitope mapping

PLoS Negl Trop Dis
PMCID: 5529020
PMID: 28708892
DOI: 10.1371/journal.pntd.0005768

[…] A peptide was considered similar to a recognized peptide if no more than three residues were different between the pair. The resulting core sequences, including sum of scores, were analyzed using the SigniSite 2.1 algorithm to identify residues associated with high or low sum of scores []. Like above, the significance threshold was set to α = 0.05. The results were illustrated as sequence logos us […]


Characterization and functional analysis of hypoxia inducible factor HIF1α and its inhibitor HIF1αn in tilapia

PLoS One
PMCID: 5344420
PMID: 28278251
DOI: 10.1371/journal.pone.0173478

[…] α and HIF1αn sequences under adaptive evolution to the aquatic environments, we first identified the functional determination sites in the protein sequences between fish and land animals by using the SigniSite 2.1 Server (, ). The HIF1α alignment has an aligned length of 1056 positions. A total of 3295 tests were performed at a significance level of 5.00% (α = 0.05 […]


Identification of a Major Dimorphic Region in the Functionally Critical N Terminal ID1 Domain of VAR2CSA

PLoS One
PMCID: 4579133
PMID: 26393516
DOI: 10.1371/journal.pone.0137695

[…] Association of specific sequence motifs with clinical or parasitological parameters was investigated by a genotype-phenotype correlation analysis based on the protein multiple sequence alignment. The SigniSite 2.1 server [] was used for quantitative phenotypes (GA [weeks], peripheral blood parasite density [parasites/μL of blood], and CSPG-binding density [parasites/mm2]). The SPEER-Server [] was […]


Insight into Antigenic Diversity of VAR2CSA DBL5ε Domain from Multiple Plasmodium falciparum Placental Isolates

PLoS One
PMCID: 2948511
PMID: 20957045
DOI: 10.1371/journal.pone.0013105

[…] A statistical In silico analysis of the multiple alignment was performed using the SigniSite server . Briefly: The SigniSite server performs a non-parametric statistical evaluation of the distribution of each residue at each position, aiming at identifying any significant associatio […]


Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal

Malar J
PMCID: 2893538
PMID: 20553578
DOI: 10.1186/1475-2875-9-165

[…] positive selection are located on the surface of both sides of the model and many are located in loops. Comparison of positions identified to be under positive selection with positions identified by SigniSite analysis, among sequences from cerebral malaria patients and from pregnant women, showed that only one position was redundant (Figure and ). None of the residues identified by SigniSite to […]


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SigniSite institution(s)
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kemitorvet, Lyngby, Denmark

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