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SigniSite specifications


Unique identifier OMICS_04923
Name SigniSite
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Leon Jessen <>

Publication for SigniSite

SigniSite in publications

PMCID: 5529020
PMID: 28708892
DOI: 10.1371/journal.pntd.0005768

[…] peptide was considered similar to a recognized peptide if no more than three residues were different between the pair. the resulting core sequences, including sum of scores, were analyzed using the signisite 2.1 algorithm to identify residues associated with high or low sum of scores []. like above, the significance threshold was set to α = 0.05. the results were illustrated as sequence logos […]

PMCID: 5344420
PMID: 28278251
DOI: 10.1371/journal.pone.0173478

[…] drawn with the software mega7 []. branches were transformed as cladogram., the significant associated residues in hif1α and hif1αn proteins between fishes and land animals were identified by the signisite 2.1 server ( []., the codeml program from the phylogenetic analysis by maximum likelihood (paml) package (available […]

PMCID: 4579133
PMID: 26393516
DOI: 10.1371/journal.pone.0137695

[…] of specific sequence motifs with clinical or parasitological parameters was investigated by a genotype-phenotype correlation analysis based on the protein multiple sequence alignment. the signisite 2.1 server [] was used for quantitative phenotypes (ga [weeks], peripheral blood parasite density [parasites/μl of blood], and cspg-binding density [parasites/mm2]). the speer-server [] […]

PMCID: 2948511
PMID: 20957045
DOI: 10.1371/journal.pone.0013105

[…] women . in order to assess such sequence variation behaviour in another highly immunogenic and conserved var2csa domain, all dbl5ε sequences generated from cdna of pam isolates were analysed using signisite . analysis revealed that certain amino acids of var2csa dbl5ε+id5 sequences appear to be of particular interest. in the multiple alignment of all dbl5ε sequences, significantly distributed […]

PMCID: 2893538
PMID: 20553578
DOI: 10.1186/1475-2875-9-165

[…] two alternative sets of dbl5ε + id5 sequences were included in the analysis: 21 sequences were from 11 isolates of cerebral malaria patients, and 19 sequences from 10 nulligravid infected women. the signisite method was used for identifying positions which have differing amino acids correlated to the ranking of sequences (hoof et al submitted). analysis of sequences from pam isolates according […]

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SigniSite institution(s)
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kemitorvet, Lyngby, Denmark

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