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Simcyp Simulator specifications


Unique identifier OMICS_35320
Name Simcyp Simulator
Stability Stable
Maintained Yes


No version available

Simcyp Simulator citations


Using a Vancomycin PBPK Model in Special Populations to Elucidate Case‐Based Clinical PK Observations

PMCID: 5915605
PMID: 29446256
DOI: 10.1002/psp4.12279

[…] Simcyp simulator software (Simcyp, Sheffield, UK; version 16 for pediatric simulations and version 14 for the others) was used to develop a vancomycin PBPK model. Vancomycin‐specific parameters, such […]


Guiding dose adjustment of amlodipine after co administration with ritonavir containing regimens using a physiologically based pharmacokinetic/pharmacodynamic model

J Pharmacokinet Pharmacodyn
PMCID: 5953987
PMID: 29427135
DOI: 10.1007/s10928-018-9574-0

[…] ined from multiple references and are summarized by multiple Simcyp-specific publications. [–]. Enzyme expression and turnover values for specific enzymes including CYP3A4/3A5 are built-in within the Simcyp simulator and these have been verified/validated in multiple instances separately [, ]. The “population representative” virtual healthy volunteer was used within Simcyp® for the optimization of […]


Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

PMCID: 5824116
PMID: 29349870
DOI: 10.1002/psp4.12274

[…] logical parameters, including the tissue volume and blood flow, milk pH, and the milk intake, along with individual physiological parameters and their variability. The model was integrated within the Simcyp Simulator using a first order absorption model and the Rodgers & Rowland method to predict the partition of drugs between tissues and plasma. In addition, the elimination kinetics of administer […]


Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

PMCID: 5817210
PMID: 29531576
DOI: 10.1155/2018/3719703

[…] (inhibition values of four main cardiac ionic currents), and study-dependent parameters (time of the day when the drug was taken). All of the above-mentioned parameters were generated with the use of Simcyp Simulator. The final data set consisted of 10,360 records representing QT interval durations for 63 patients taking terfenadine alone or with the concomitant drug in different time points of cl […]


In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

PMCID: 5849655
PMID: 29273968
DOI: 10.1007/s00228-017-2404-2

[…] PK parameters were calculated, and statistical analyses were performed using a SimCYP simulator (V9 and 16). All the simulated areas under the concentration–time curve (AUC) values were calculated up to the last time point (AUClast) by using the SimCYP simulation software. The h […]


Prediction of Drug Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically Based Pharmacokinetic Model

PMCID: 5874814
PMID: 29267251
DOI: 10.3390/pharmaceutics10010001

[…] el was used for the prediction of the involvement and impact of inhibitory metabolites in DDIs. Bufuralol, tolterodine, metoprolol, desipramine, and dextromethorphan as the CYP2D6 substrates from the Simcyp simulator library were used to simulate the DDIs. In addition, the PBPK model of venlafaxine was also built to simulate the DDI with bupropion. The observed clinical data were digitized from th […]


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