SimHap statistics

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Citations per year

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Tool usage distribution map

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Associated diseases

Associated diseases

SimHap specifications


Unique identifier OMICS_00246
Name SimHap
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Medium
Stability Stable
Maintained Yes


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Publication for SimHap

SimHap in publications

PMCID: 4019480
PMID: 24823657
DOI: 10.1371/journal.pone.0096306

[…] analyze the effects of multiple covariates on a continuous outcome. haplotypes were inferred for individuals with ambiguous phase, and the haplotype frequencies were estimated and analyzed using the simhap software . p-values <0.0125 were designated as significant based on the bonferroni correction for multiple comparisons of the four htsnps, which were evaluated as independent statistical […]

PMCID: 3598639
PMID: 23351195
DOI: 10.1186/1471-2350-14-15

[…] using a natural logarithm transformation prior to analysis. associations between transformed values and genotypes at each tsnp were examined using a generalised linear model approach implemented in simhap []. each polymorphism was modelled as a genotypic (codominant) genetic effect, accommodating the effects of age, gender, and bmi as significant covariates. we determined marginal geometric […]

PMCID: 3419947
PMID: 22767148
DOI: 10.1038/bjc.2012.290

[…] adverse reactions)., statistical analysis used spss v16.0 (ibm software, armonk, ny, usa). genetic analysis was carried out using the plink v1.07 ( and simhap v1.02 ( software/simhap). for calculation of empirical p-values 20 000 permutations were performed., in all, 43 candidate snps were genotyped in 35 genes, […]

PMCID: 3388377
PMID: 22778957
DOI: 10.1155/2012/231309

[…] and 40 sex- and age-matched controls were included; all were nonsmokers and free of systemic diseases. genotyping at each locus was performed using an established pcr-rflp assay. the haploview and simhap software were used to assess data for hardy-weinberg's equilibrium (hwe) and linkage disequilibrium (ld) and to obtain subject-level haplotypes. multiple logistic regression was used to seek […]

PMCID: 3266204
PMID: 22107728
DOI: 10.1186/1471-2350-12-151

[…] of test statistic distributions under the null and alternative hypothesis. all association and power analyses were performed in r version 2.10.0 using the packages geepack, pwr, powermediation and simhap (all obtained from, we examined the associations of ide snps (ide2, rs4646953; ide7, rs2251101; ide9, rs1887922) and derived haplotypes (on the coding strand […]

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SimHap institution(s)
Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia

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