SimHap

[…] analyze the effects of multiple covariates on a continuous outcome. haplotypes were inferred for individuals with ambiguous phase, and the haplotype frequencies were estimated and analyzed using the simhap software . p-values <0.0125 were designated as significant based on the bonferroni correction for multiple comparisons of the four htsnps, which were evaluated as independent statistical […]

[…] using a natural logarithm transformation prior to analysis. associations between transformed values and genotypes at each tsnp were examined using a generalised linear model approach implemented in simhap []. each polymorphism was modelled as a genotypic (codominant) genetic effect, accommodating the effects of age, gender, and bmi as significant covariates. we determined marginal geometric […]

[…] adverse reactions)., statistical analysis used spss v16.0 (ibm software, armonk, ny, usa). genetic analysis was carried out using the plink v1.07 (http://pngu.mgh.harvard.edu/purcell/plink/) and simhap v1.02 (http://www.genepi.meddent.uwa.edu.au/ software/simhap). for calculation of empirical p-values 20 000 permutations were performed., in all, 43 candidate snps were genotyped in 35 genes, […]

[…] and 40 sex- and age-matched controls were included; all were nonsmokers and free of systemic diseases. genotyping at each locus was performed using an established pcr-rflp assay. the haploview and simhap software were used to assess data for hardy-weinberg's equilibrium (hwe) and linkage disequilibrium (ld) and to obtain subject-level haplotypes. multiple logistic regression was used to seek […]

[…] of test statistic distributions under the null and alternative hypothesis. all association and power analyses were performed in r version 2.10.0 using the packages geepack, pwr, powermediation and simhap (all obtained from http://www.r-project.org)., we examined the associations of ide snps (ide2, rs4646953; ide7, rs2251101; ide9, rs1887922) and derived haplotypes (on the coding strand […]