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An interactive program that integrates generation of rare variant genotype/phenotype data and evaluation of association methods using a unified platform. Variant data are generated for gene regions using forward-time simulation that incorporates realistic population demographic and evolutionary scenarios. Phenotype data can be obtained for both case–control and quantitative traits. SimRare has a user-friendly interface that allows for easy entry of genetic and phenotypic parameters. Novel rare variant association methods implemented in R can also be imported into SimRare, to evaluate their performance and compare results, e.g. power and Type I error, with other currently available methods both numerically and graphically.

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SimRare classification

SimRare specifications

Software type:
Restrictions to use:
Programming languages:
C++, Python
Computer skills:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
GNU General Public License version 2.0

SimRare distribution


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Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

Link to literature

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