SimuCell

[…] between these three lines. lehmussola et al. describe a cell shape model based on deformed regular polygons with cell texture generate with perlin noise []. the method is extended in the framework simucell []. in [] cells and nuclei are modeled using basic geometric shapes such as circles and ellipses and the borders are then varied. also some variations in illumination and noise […]

[…] from voronoi diagrams and does not reflect the variety of cell phenotypes found in real tissue. heterogeneous cell populations expressing different protein markers can be simulated using the simucell toolbox []. the first method for simulating bright-field microscopy was proposed for synthesising cervical smears []. however, tissue microenvironment was not taken into account […]

[…] from the voronoi diagrams and does not reflect the variety of cell phenotypes found in real tissue. heterogeneous cell populations expressing different protein markers can be simulated using the simucell toolbox []. on the other hand, zhao et al. [] presented a machine learning method to generate realistic cells with labelled nuclei, membranes and a protein expressed in a cell organelle. […]