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Single-cell assembly software tools | Single-cell DNA sequencing data analysis

Whole genome amplification by the multiple displacement amplification (MDA) method allows sequencing of genomes from single cells of bacteria that cannot be cultured. However, genome assembly is challenging because of highly non-uniform read coverage generated by MDA.

Source text:
(Lasken, 2012) Genomic sequencing of uncultured microorganisms from single cells. Nat Rev Microbiol.

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