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SIREs specifications


Unique identifier OMICS_06167
Name SIREs
Alternative name Search for iron-responsive elements
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Search for iron-responsive elements

SIREs citations


Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells

Int J Mol Sci
PMCID: 4519909
PMID: 26184159
DOI: 10.3390/ijms160715481

[…] Mouse TfR1 (NM_011638.4) and Fth1 (NM_010239.2) cDNAs were synthesised from a RNA sample of the MSC D1 line. Iron responsive elements were identified using SIREs Web Server 2.0 software [] and excluded from amplification, to avoid the cell’s post-transcriptional control of these genes. TfR1 and Fth1 cDNAs were then cloned into pHIV-eGFP (Addgene, Cambrid […]


Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

PMCID: 4832581
PMID: 25870938
DOI: 10.1111/nan.12242

[…] een PKAN and COPAN, such as reduced acyl‐CoA and lipid synthesis leading to mitochondrial insufficiencies.Of the 10 NBIA‐related genes, only COASY shows a putative iron response element (IRE) via the SIREs 2.0 prediction tool ( The sequence is a putative 3′ IRE and would lead to mRNA stabilization in the presence of iron. This could potentially link COASY expression t […]


Novel Single Nucleotide Polymorphisms of the Insulin Like Growth Factor I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)

Int J Mol Sci
PMCID: 4284719
PMID: 25486058
DOI: 10.3390/ijms151222471
call_split See protocol

[…] PCR products from at least 6 sires, 6 dams and 5 progenies were initially cloned and sequenced to detect polymorphisms of common carp IGF-I in the test population. Sequences were aligned using Clustal X program [] for polymorphis […]


Gene Expression Profiling in Entamoeba histolytica Identifies Key Components in Iron Uptake and Metabolism

PLoS One
PMCID: 4161402
PMID: 25210888
DOI: 10.1371/journal.pone.0107102

[…] IRPs. Iron-responsive elements have been found in both the 5′ and 3′ untranslated regions (UTRs) of mRNAs and also in regions coding for proteins involved in iron transport and storage –. We used the SIREs web server to identify potential IRE structures in the E. histolytica transcripts identified by the microarray analysis . We analyzed the 5′-UTR, 3′-UTR and coding mRNA sequences extracted from […]


Cloning and Characterisation of Multiple Ferritin Isoforms in the Atlantic Salmon (Salmo salar)

PLoS One
PMCID: 4117605
PMID: 25078784
DOI: 10.1371/journal.pone.0103729

[…] eotide BLAST searches were conducted against the NCBI GenBank to retrieve the respective full-length EST sequences. The EST sequences were used to predict the presence of IREs in the 5′-UTR using the SIREs web server tool ( . […]


Raised Serum Ferritin Concentration in Hereditary Hyperferritinemia Cataract Syndrome Is Not a Marker for Iron Overload

PMCID: 4296220
PMID: 24003015
DOI: 10.1002/hep.26681

[…] d-type. A heterozygous c.-160A>G mutation was identified in the IRE within the 5′ untranslated region (5′-UTR) of FTL, in the patient and his mother (B). Bioinformatic analysis ( predicted that the mutant messenger RNA (mRNA) will not form the regulatory IRE “hairpin” structure (C). These results confirmed a diagnosis of HHCS. Subsequent investigation showed […]


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SIREs institution(s)
European Molecular Biology Laboratory, Heidelberg, Germany

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