SLITHER specifications


Unique identifier OMICS_07214
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for SLITHER

SLITHER citations


Deorphanizing the human transmembrane genome: A landscape of uncharacterized membrane proteins

Acta Pharmacol Sin
PMCID: 3880479
PMID: 24241348
DOI: 10.1038/aps.2013.142

[…] dimensional structure correlated with classifications or functional parameters, methods have also been developed to directly infer function based on a three dimensional conformation. For example, the SLITHER program uses molecular modeling simulations to predict whether a putative substrate molecule may permeate the cavities or channels in a protein structure. In cases where the existence of a cha […]


Structural Analysis of Prolyl Oligopeptidases Using Molecular Docking and Dynamics: Insights into Conformational Changes and Ligand Binding

PLoS One
PMCID: 3223163
PMID: 22132071
DOI: 10.1371/journal.pone.0026251

[…] Cleavage of any small peptide like angiotensin-IV by POP produces two N- and C-terminal products. SLITHER generates contiguous conformations of ligand across the tunnel. Docking of smaller product in porcine POP (C-terminal) by SLITHER showed that its egress can be through β-propeller pore. Diffe […]

SLITHER institution(s)
Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan

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