A structural database of small molecule-transcription factor complexes. The 3D structures of the co-bound small molecule and the corresponding binding sites on transcription factors (TFs) are provided in the database, serving as a valuable resource to assist structure-based drug design related to TFs. Currently, the SM-TF database contains 934 entries covering 176 TFs from a variety of species. The database is further classified into several subsets by species and organisms. The entries in the SM-TF database are linked to the UniProt database and other sequence-based TF databases. Furthermore, the druggable TFs from human and the corresponding approved drugs are linked to the DrugBank.
Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA; Department of Physics and Astronomy, University of Missouri, Columbia, MO, USA; Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA; Department of Biochemistry, University of Missouri, Columbia, MO, USA; Informatics Institute, University of Missouri, Columbia, MO, USA
SM-TF funding source(s)
NSF CAREER Award (DBI-0953839); American Heart Association (13GRNT16990076); National Institutes of Health (R01GM109980)