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SMART specifications


Unique identifier OMICS_03875
Alternative name Simple Modular Architecture Research Tool
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


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Publications for Simple Modular Architecture Research Tool

SMART citations


Molecular characterization and expression patterns of a non mammalian toll like receptor gene (TLR21) in larvae ontogeny of common carp (Cyprinus carpio L.) and upon immune stimulation

PMCID: 5934810
PMID: 29724212
DOI: 10.1186/s12917-018-1474-4
call_split See protocol

[…] apid amplification of the cDNA ends) using the 3′-full and 5′-full RACE core set (TaKaRa). The primers used are shown in Table .The structural domains of CcTLR21 were characterized using the SMART (a simple modular architecture research tool) program ( The amino acid sequence alignment of TLR21s was performed with MegAlign in DNAstar 7.0 using the method of Clusta […]


A Novel G Protein Coupled Receptors Gene from Upland Cotton Enhances Salt Stress Tolerance in Transgenic Arabidopsis

PMCID: 5924551
PMID: 29649144
DOI: 10.3390/genes9040209

[…] confirm the presence of the TOM domain, two online tools were later used for further analysis: the ScanProsite tool (, Swiss Institute of Bioinformatics) and the Simple Modular Architecture Research Tool (SMART) program ( SMART and Pfam databases were used to verify the presence of the TOM gene domains. The isoelectric points […]


Functional Characterization of the alb1 Orthologue Gene in the Ochratoxigenic Fungus Aspergillus carbonarius (AC49 strain)

PMCID: 5869408
PMID: 29534508
DOI: 10.3390/toxins10030120
call_split See protocol

[…] to identify orthologue genes in other fungi.The amino acid sequences of the ALB1 acetyl-transferase (AT) domain of 21 Aspergillus species and other 15 genera of Ascomycetes were obtained by using the Simple Modular Architecture Research Tool (SMART; The domain sequences were then aligned through MEGA6 software [] with the MUSCLE algorithm, and the phylogenetic tr […]


A recombinant Fasciola gigantica 14 3 3 epsilon protein (rFg14 3 3e) modulates various functions of goat peripheral blood mononuclear cells

PMCID: 5840819
PMID: 29510740
DOI: 10.1186/s13071-018-2745-4

[…] cifically, the protein sequence was first subjected to the prediction of sequence domain, followed by comparative analysis and 3D modelling. The presence of sequence domain was performed using SMART (Simple Modular Architecture Research Tool) []. Next, a comparative analysis was done to search for similarities in protein sequence databases (NCBI non-redundant protein sequence) and to identify poss […]


Genome Wide Identification and Characterization of WD40 Protein Genes in the Silkworm, Bombyx mori

Int J Mol Sci
PMCID: 5855749
PMID: 29425159
DOI: 10.3390/ijms19020527

[…] t (PF00400). Redundant sequences were discarded manually. The presence of WD40 repeats was confirmed by CDD (Conserved Domain Database, [], SMART (Simple Modular Architecture Research Tool, [] and WDSP (WD40-repeat Protein Structure Predictor, [] search-based domai […]


A Novel Bifunctional Endolytic Alginate Lyase with Variable Alginate Degrading Modes and Versatile Monosaccharide Producing Properties

Front Microbiol
PMCID: 5809466
PMID: 29472911
DOI: 10.3389/fmicb.2018.00167

[…] erver. The molecular mass of the protein was estimated using the peptide mass tool on the ExPASy server of the Swiss Institute of Bioinformatics. Protein modules and domains were identified using the Simple Modular Architecture Research Tool (SMART). Multiple sequence alignments and phylogenetic analyses were performed using MEGA version 6.01 (). […]


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SMART institution(s)
Biobyte solutions GmbH, Heidelberg, Germany; EMBL, Heidelberg, Germany; EMBL, Heidelberg, Germany
SMART funding source(s)
Supported by the German Network for Bioinformatics Infrastructure (de.NBI) and EMBL.

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