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SNAP specifications


Unique identifier OMICS_00162
Alternative name Screening for Non-Acceptable Polymorphisms
Interface Web user interface
Restrictions to use None
Input data A protein sequence
Input format FASTA
Computer skills Basic
Version 2.0
Stability Stable
Maintained Yes

Publications for Screening for Non-Acceptable Polymorphisms

SNAP citations


Germline Variants in the POT1 Gene in High Risk Melanoma Patients in Austria

PMCID: 5940141
PMID: 29523635
DOI: 10.1534/g3.117.300394

[…] ; ): MutationTaster2 (), PolyPhen-2 (Polymorphism Phenotyping-v2, HumDiv and HumVar) (), PROVEAN (Protein Variation Effect Analyzer) (), SIFT (sorts intolerant from tolerant substitutions) (), SNAP2 (screening for non-acceptable polymorphisms-2) (), PANTHER (Protein ANalysis THrough Evolutionary Relationships) (), CADD (Combined Annotation Dependent Depletion) (), GERP++ () and phyloP (). For the […]


A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm 3 and nphp 4

PLoS Genet
PMCID: 4749664
PMID: 26863025
DOI: 10.1371/journal.pgen.1005841

[…] ) and falls within an overall conserved domain found across many different kinesin family members. The specific S316F substitution is not listed in the human SNP database (dbSNP version 132), and the Screening for Non-acceptable Polymorphisms program (SNAP) ( predicts that the S316F substitution is non-neutral with 78% accuracy. To confirm that the osm-3(yhw66) […]


Human Thromboxane A2 Receptor Genetic Variants: In Silico, In Vitro and “In Platelet” Analysis

PLoS One
PMCID: 3696120
PMID: 23840660
DOI: 10.1371/journal.pone.0067314

[…] od of a protein to tolerate each of the twenty amino acids at each position in the protein. Output values for each amino acid change tolerance from SIFT ranges from 0 (damaging) to 1 (neutral). SNAP (screening for non-acceptable polymorphisms) ( incorporates SIFT predictions along with PSI-BLAST alignment conservation, while incorporating additional sequence i […]


Discovery of Candidate Disease Genes in ENU–Induced Mouse Mutants by Large Scale Sequencing, Including a Splice Site Mutation in Nucleoredoxin

PLoS Genet
PMCID: 2782131
PMID: 20011118
DOI: 10.1371/journal.pgen.1000759

[…] omolog (Fzd2) and a glutamine to proline substitution (Q341P) in the plexin domain containing 1 gene (Plxdc1).To predict the likelihood that an amino acid change is deleterious, we employed the SNAP (screening for non-acceptable polymorphisms) algorithm using default parameters and full-length protein coding sequences . It predicts the neutrality of the mutation, calculates the percent accuracy of […]


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SNAP institution(s)
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA

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