Snooker specifications


Unique identifier OMICS_33120
Name Snooker

Publication for Snooker

Snooker citations


Snooker Structure Based Pharmacophore Model Explains Differences in Agonist and Blocker Binding to Bitter Receptor hTAS2R39

PLoS One
PMCID: 4346584
PMID: 25729848
DOI: 10.1371/journal.pone.0118200

[…] With the structure-based pharmacophore model derived with Snooker details about receptor binding sites at a molecular level can be proposed, which are in accordance to amino acids mentioned in related studies. Furthermore, the structure-based pharmacophore m […]


In Silico Veritas: The Pitfalls and Challenges of Predicting GPCR Ligand Interactions

PMCID: 4058654
DOI: 10.3390/ph4091196

[…] deled using pharmacophore searches followed by flexible receptor docking. Structure-based pharmacophores derived from the transmembrane domains of the constructed homology models were built using the Snooker program []. In short, the Snooker method scores residue positions based on sequence conservation in a multiple sequence alignment, and deduces the key interacting residues from the derived sta […]

Snooker institution(s)
Computational Drug Discovery Group, CMBI, Radboud University Nijmegen, Nijmegen, The Netherlands; Department of Molecular Design and Informatics, MRL, MSD, Oss, The Netherlands; Division of Medicinal Chemistry, LACDR, VU University Amsterdam, Amsterdam, The Netherlands; Modeling and Data Mining Group, CMBI, Radboud University Nijmegen, Nijmegen, The Netherlands
Snooker funding source(s)
Supported by the BioRange program of these Netherlands Bioinformatics Centre (NBIC), which is supported by a BSIK grant through the Netherlands Genomics Initiative (NGI), the EMBRACE project that is funded by the European Commission within its FP6 Programme, under the thematic area “Life sciences, genomics and biotechnology for health”, contract number LHSG-CT-2004-512092, and by TIPharma.

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