A large-scale database of genetics and genomics data associated to a web-interface and a set of methods and algorithms that can be used for mining the data in it. The database contains two categories of single nucleotide polymorphism (SNP) annotations: 1) Physical-based annotation where SNPs are categorized according to their position relative to genes (intronic, inter-genic, etc.) and according to linkage disequilibrium (LD) patterns (an inter-genic SNP can be annotated to a gene if it is in LD with variation in the gene); 2) Functional annotation where SNPs are classified according to their effects on expression levels, i.e. whether they are expression quantitative trait loci (eQTLs) for that gene.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang Province, China; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA; Biological Resources Laboratory, University of Illinois at Chicago, Chicago, IL, USA