Finds proxy single nucleotides polymorphisms (SNPs) based on linkage disequilibrium (LD). SNAP includes features to: (i) detect SNP proxies in genes, (ii) shape fine mapping boundaries, (iii) verify SNPid aliases along dbSNP builds, (iv) determine annotations for SNPs of interest or (v) create association and graphical plots of proxies for a queried SNP. It aims to assist users in performing cross- genome-wide association studies (GWAS) comparisons.
The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine, Framingham, MA; Broad Institute of MIT and Harvard, Cambridge, MA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School-Partners HealthCare Center for Genetics and Genomics, Boston, MA; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
SNAP funding source(s)
Supported by NHLBI's Framingham Heart Study (N01-HC-25195); Intramural training program of the NHLBI; and a NHLBI CARe (Candidate Gene Association Resource) grant (N01-HC-65226).