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Single nucleotide polymorphism identification software tools | Pool sequencing data analysis

Single nucleotide polymorphism identification software tools | Pool sequencing data analysis

Detecting single-nucleotide polymorphism (SNP) in pooled sequencing data is more challenging than in individual sequencing because of sampling variations across pools. To effectively differentiate SNP signal from sequencing error, appropriate estimation of the sequencing error is necessary.

Source text:
(Zhou, 2012) An empirical Bayes mixture model for SNP detection in pooled sequencing data. Bioinformatics.

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