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Evolutionary Dynamics of Co Segregating Gene Clusters Associated with Complex Diseases
[…] f positive selection and selective sweeps in regions of low recombination using the publicly available data from the Haplotter tool provided by Voight et al. (http://haplotter.uchicago.edu/) and the [email protected] database (http://bighapmap.big.ac.cn/) . We captured multiple signals of positive selection across conserved hitchhiked regions including empirical values of heterozygosity (HET), FST va […]
The PLIN4 Variant rs8887 Modulates Obesity Related Phenotypes in Humans through Creation of a Novel miR 522 Seed Site
[…] tions in the final dataset. Evolutionary analyses were conducted in MEGA4. Total and population FST statistics for HapMap populations where estimated using the [email protected] webtool which implements the FST calculations described in Akey et al . […]
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9
[…] S (integrated haplotype score statistic, used for scanning single nucleotide polymorphism data for signals of selection were recovered from the Haplotter http://haplotter.uchicago.edu/selection/ and [email protected] (http://bighapmap.big.ac.cn/) databases. […]
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