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SNPeffect | On-line prediction of molecular and structural effects of protein-coding variants


Provides information about phenotyping human single nucleotide polymorphisms (SNPs). SNPeffect is a database that allows users to search SNVs by filtering on molecular phenotypic effects, mutation type, disease, UniProt identifier, dbSNP identifier and gene name. Users can also analyze and plot phenotypic features of a specific subset (or all) of the SNPeffect database. It also includes a data submission framework for submitting (human or non-human) custom single protein variants for a detailed SNPeffect analysis including TANGO, WALTZ, LIMBO and FoldX.

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SNPeffect classification

  • Animals
    • Homo sapiens

SNPeffect specifications

Unique identifier:
Database management system:
Data access:
File download, Browse
Restrictions to use:
Community driven:
User data submission:
Not allowed

SNPeffect support



  • Frederic Rousseau <>
  • Joost Schymkowitz <>


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VIB Switch Laboratory, Leuven, Belgium ; Department of Molecular Cell Biology, University of Leuven, Leuven, Belgium ; Vrije Universiteit Brussel, Brussel, Belgium; Vesalius Research Center, VIB, Leuven, Belgium; Vesalius Research Center, University of Leuven, Leuven, Belgium; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Bioinformatics, Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain; Functional Genomics Node (INB) at CIPF, Valencia, Spain

Funding source(s)

Supported by Interuniversity Attraction Poles (IAP Network 6/43) of the Belgian Federal Science Policy Office (BelSPo) (VIB Switch laboratory); Flanders Institute for Science and Technology (IWT), Fund for Scientific Research (FWO), Flanders, MICINN projects BIO2008-04212, and RD06/0020/1019 (RTICC,
ISCIII) (Dopazo lab, partial) GVA-FEDER (PROMETEO/2010/001, partial).

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