Assigns molecular functional effects of non-synonymous SNPs based on structure and sequence analysis. There are three unique features of the SNPs3D resource. First, it is designed specifically for the analysis of the relationship between SNPs and disease. Second, it constructs gene networks based on conceptual relationships derived from the literature, rather than experimental data. Third, it integrates access to all available and relevant information sources, wherever possible giving the user easy access to the underlying data and literature, so that informed judgments can be made.