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SOLAR specifications


Unique identifier OMICS_09413
Alternative name Sequential Oligogenic Linkage Analysis Routines
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Computer skills Advanced
Version 7.6.4
Stability Stable
Maintained Yes


No version available


  • person_outline SOLAR

Publication for Sequential Oligogenic Linkage Analysis Routines

SOLAR citations


Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS)

Sci Rep
PMCID: 5884862
PMID: 29618726
DOI: 10.1038/s41598-018-23727-2
call_split See protocol

[…] healthy with a lipid medication rate of 3.9%. Therefore, only a single regression model was performed without accounting for lipid medication status. Heritability of lipid levels was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR) adjusting for age, sex, body mass index (BMI), and recruitment center. Variants with Mendelian inconsistencies were removed (n = 4,024), resulti […]


Transmissibility and familiality of NEO personality dimensions in a sample of South Korean families with schizophrenia

PMCID: 5841977
PMID: 29465570
DOI: 10.1097/MD.0000000000009858

[…] The heritability of personality dimensions was estimated in a total of 543 family members using Sequential Oligogenic Linkage Analysis Routines (SOLAR).[] The SOLAR is an extensive, flexible software package for genetic variance components analysis, including linkage analysis, quantitative genet […]


Heritability of the melatonin synthesis variability in autism spectrum disorders

Sci Rep
PMCID: 5735101
PMID: 29255243
DOI: 10.1038/s41598-017-18016-3
call_split See protocol

[…] ribution (Supplementary Fig. ). Since melatonin and serotonin are known to be age and sex dependent–, they were included in the models using residuals from regression models obtained with the program Sequential Oligogenic Linkage Analysis Routines (SOLAR) 7.2.5 (Southern Foundation for Biomedical Research, San Antonio, TX, USA),, when their effect as covariates (age, sex) were significant at the t […]


Factors influencing the age at onset in familial frontotemporal lobar dementia

PMCID: 5730818
PMID: 29264395
DOI: 10.1212/NXG.0000000000000203

[…] The heritability of traits was estimated using a variance components method as implemented in the SOLAR v8.1.4 (Sequential Oligogenic Linkage Analysis Routines) computer package. Briefly, this method applies maximum likelihood estimation to a mixed-effects model that incorporates fixed effects for known covaria […]


Taste Responses to Linoleic Acid: A Crowdsourced Population Study

PMCID: 5863569
PMID: 28968903
DOI: 10.1093/chemse/bjx058

[…] sing a likelihood ratio statistic. Here, significance is based on a 0.5:0.5 mixture of a Chi-squared distribution with 1 degree of freedom and a point mass at 0. Analyses were conducted in the SOLAR [Sequential Oligogenic Linkage Analysis Routines] software package (). Throughout, statistical significance was assessed at a type 1 error of 0.05 as this was an initial/exploratory study. […]


Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree based measured genotype association analysis

BMC Med Genet
PMCID: 5516337
PMID: 28720088
DOI: 10.1186/s12881-017-0435-2

[…] yses, a two-tailed p value of <0.05 was considered statistically significant. Statistical analyses were performed with SPSS 23.0 (Statistical Package for Social Sciences, SPSS Inc., Chicago, Ill) and Sequential Oligogenic Linkage Analysis Routines software (SOLAR) [] available at […]


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SOLAR institution(s)
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, USA

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