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SOLpro specifications

Information


Unique identifier OMICS_08048
Name SOLpro
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data Protein sequence
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes

Versioning


No version available

Maintainer


  • person_outline Pierre Baldi <>

Information


Unique identifier OMICS_08048
Name SOLpro
Interface Web user interface
Restrictions to use None
Input data Protein sequence
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Pierre Baldi <>

Publication for SOLpro

SOLpro citations

 (8)
library_books

Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity

2017
PMCID: 5573320
PMID: 28842596
DOI: 10.1038/s41598-017-09749-2

[…] remains difficult because various factors such as the size of polypeptides, total protein charge, and phylogenetic origin affect the solubility of target proteins, . computational methods such as solpro and proso ii have been developed to estimate whether a given target protein would be soluble in a heterologous expression system. pross can optimize the sequence of a target protein to improve […]

library_books

Comparative Genomics Reveals Two Major Bouts of Gene Retroposition Coinciding with Crucial Periods of Symbiodinium Evolution

2017
PMCID: 5585692
PMID: 28903461
DOI: 10.1093/gbe/evx144

[…] the complexity of sequences was calculated using an entropy formula: s=∑a,t,c,g-pn lnpn, where p(n) represents the frequency of base n in a given sequence. protein solubility was predicted using solpro, a sequence-based predictor ()., the differences of the tested terms were analyzed by student’s t test after a shapiro–wilk test using the t.test and shapiro.test r packages, respectively. […]

library_books

Production of unstable proteins through the formation of stable core complexes

2016
PMCID: 4800440
PMID: 26983699
DOI: 10.1038/ncomms10932

[…] sequence alignments were performed using the pipealign software. coupled with the multiple alignments, disorder analysis (pondr-fit and iupred), domain prediction (cdd), solubility predictions (solpro in scratch programme suite and proso) and secondary structures predictions (jpred) were performed. the analysis of the predictions of secondary and intrinsically disordered regions was used […]

library_books

Enhanced expression of codon optimized Mycobacterium avium subsp. paratuberculosis antigens in Lactobacillus salivarius

2014
PMCID: 4154528
PMID: 25237653
DOI: 10.3389/fcimb.2014.00120

[…] suggesting the presence of aggregated gfp fusion proteins within the cytoplasm of l. salivarius (figure ). this result was not expected since mmp was predicted to be more soluble than mptd using solpro1.0 software (magnan et al., )., to investigate whether the l. salivarius expressed mptd protein was analogous to the native map protein, we utilized a modified version of the fmptd […]

library_books

A review of machine learning methods to predict the solubility of overexpressed recombinant proteins in Escherichia coli

2014
PMCID: 4098780
PMID: 24885721
DOI: 10.1186/1471-2105-15-134

[…] in terms of convenience and ease of use, the ones with publicly accessible web servers can be considered the most convenient to use and evaluate. they are pros [], prosoii [], scm [], espresso [], solpro [], proso [] and the model of diaz et al. []., it seems that by using an appropriate dataset, as well as suitable machine learning techniques, reasonable prediction performance is attainable. […]

library_books

In silico experiment with an antigen toll like receptor 5 agonist fusion construct for immunogenic application to Helicobacter pylori

2013
PMCID: 3722629
PMID: 23901192
DOI: 10.4103/0971-6866.112885

[…] was further analyzed by swiss-pdb viewer for energy minimization. prediction of solubility upon overexpression[] and antigenicity of recombinant proteins were performed with online programs such as solpro and antigenpro http://scratch.proteomics.ics.uci.edu/., the alignment of caga, nap and oipa amino acid sequences of different h. pylori strains resulted in the identification of three […]


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SOLpro institution(s)
Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, CA, USA

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