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Solubility mutagenesis detection software tools | Protein structure data analysis

Solubility is one of the fundamental protein properties. It is of great interest because of its relevance to protein expression. Reduced solubility and protein aggregation are also associated with many diseases.Source text:(Yang et al., 2016)…
PON-Sol
Web

PON-Sol

Predicts the effects of amino acid substitution on protein solubility. PON-Sol…

Predicts the effects of amino acid substitution on protein solubility. PON-Sol is a machine learning-based method and utilizes amino acid features and evolutionary information. The predictor can…

CamSol
Web

CamSol

A method for the rational design of protein variants with enhanced solubility.…

A method for the rational design of protein variants with enhanced solubility. CamSol works by performing a rapid computational screening of tens of thousand of mutations to identify those with the…

OptSolMut
Desktop

OptSolMut

A scoring function to predict solubility mutagenesis based on the frequencies…

A scoring function to predict solubility mutagenesis based on the frequencies of triplets of AAs that have low degrees of buriedness. We develop a training method based on linear programming (LP),…

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