A database of cancer somatic mutations in microRNAs (miRNA) and their target sites that potentially alter the interactions between miRNAs and competing endogenous RNAs (ceRNA) including mRNAs, circular RNAs (circRNA) and long noncoding RNAs (lncRNA). We expanded the scope of the database by including somatic mutations that impact the interactions between miRNAs and two classes of non-coding RNAs, circRNAs and lncRNAs. A recently developed webserver, miR2GO, was integrated with the database to provide a seamless pipeline for assessing functional impacts of somatic mutations in miRNA seed regions. Data and functions from multiple sources including biological pathways and genome-wide association studies were updated and integrated with SomamiR 2.0 to make it a better platform for functional analysis of somatic mutations altering miRNA-ceRNA interactions.
Machine Intelligence Unit, Indian Statistical Institute, Kolkata, WB, India; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN, USA
SomamiR funding source(s)
The Ramalingaswami Re-entry fellowship, Department of Biotechnology, India [Project Title: Functional Annotation of Somatic Mutations in Cancer, Project Number: BT/RLF/Re-entry/09/2013]