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Somatic copy-number alteration identification software tools | DNA methylation microarray data analysis

Somatic copy-number alteration identification software tools | DNA methylation microarray data analysis The 450k platform is based on similar biochemical reaction principle and technology as the Infinium SNP arrays, making it possible to use the 450k platform to detect copy number variants (CNVs) as a zero-cost byproduct of methylation studies. CN calling consists of the following principal steps: normalization of probe intensities, calculation of the Log R Ratios (LRRs), segmentation and determination of copy number status for each segment based on a chosen cutoff level or a P-value threshold.
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