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Sorting Tolerant From Intolerant SIFT

Predicts whether an amino acid substitution affects protein function. SIFT prediction is based on the degree of conservation of amino acid residues in sequence alignments derived from closely related sequences, collected through PSI-BLAST. SIFT can be applied to naturally occurring nonsynonymous polymorphisms or laboratory-induced missense mutations.

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1 user review

1 user review

Julio Diaz Caballero's avatar image

Julio Diaz Caballero

The web interface of this software runs smoothly and relatively fast. The output is simple to understand and it is summarized In a single value (SIFT score). Nonetheless, I wanted to run a batch of predictions and tried to download and install SIFT in my computer, but that turned out to be a very difficult process. The dependencies are old and difficult to install. I emailed the author in order to get some assistance, but no reply. I think they stopped supporting SIFT in favour of PROVEAN.

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SIFT classification

  • Animals
    • Homo sapiens

SIFT specifications

Web user interface
Computer skills:
Restrictions to use:


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Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, Seattle, WA, USA

Link to literature

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