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SPAAN specifications


Unique identifier OMICS_20480
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data Sequences
Input format FASTA
Operating system Unix/Linux
Programming languages C
Computer skills Advanced
Stability Stable
C compiler
Maintained Yes


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  • person_outline Srinivasan Ramachandran

Publication for SPAAN

SPAAN citations


Basis of Virulence in Enterotoxin Mediated Staphylococcal Food Poisoning

Front Microbiol
PMCID: 5890119
PMID: 29662470
DOI: 10.3389/fmicb.2018.00436

[…] d in immune recognition and cell activation (Langley et al., ; Tuffs et al., ). Importantly, the ability of SElX to bind neutrophils, which are considered the first line of defense against S. aureus (Spaan et al., ), was crucial for disease progression in a rabbit model of necrotizing pneumonia. Together, these studies describe an unusual member of the SE family that has both superantigenic and SS […]


Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection

PMCID: 5850327
PMID: 29535203
DOI: 10.1128/mBio.02125-17

[…] ell targeting, the stem that inserts into the host cell membrane during pore formation, and the cap that covers hydrophobic residues in the stem domain. These features have been reviewed in detail by Spaan et al. (), and further studies are required to determine whether dominant epitopes for human memory B-cell-derived antibodies localize to these domains. However, it has not been established that […]


Anti adhesion Property of the Potential Probiotic Strain Lactobacillus fermentum 8711 Against Methicillin Resistant Staphylococcus aureus (MRSA)

Front Microbiol
PMCID: 5852077
PMID: 29568290
DOI: 10.3389/fmicb.2018.00411

[…] sequence was retrieved from NCBI. Adhesins of L. fermentum from the genome sequence were predicted using a Software program for Prediction of Adhesins and Adhesin-like proteins using Neural networks (SPAAN; ). SPAAN uses neural networks integrated with five different attributes like amino acid frequencies, multiplet frequencies, dipeptide frequencies, charge composition, and hydrophobic compositio […]


Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment

PMCID: 5880201
PMID: 29619416
DOI: 10.1002/hep4.1166

[…] a polarization model with overactive cytotoxic and inadequate IFN‐γ responses., , , Successful antiviral therapy, including DAAs, may result in normalization of NK cell function., , , The study by Spaan and colleagues did not include function analysis of NK cells; however, down‐regulation of NKp46, NKp30, and TRAIL, observed after daclatasvir/asunaprevir treatment, suggests that cytotoxic activ […]


Outcomes assessment of hepatitis C virus positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct Acting Antiviral agents

PMCID: 5838451
PMID: 29527268
DOI: 10.4254/wjh.v10.i2.329

[…] ule TIGIT in bulk T lymphocytes[]. Burchill et al[] observed a partial reversal of the exhausted phenotype in HCV-specific CD8+ T cells and a dampening of the activation state in peripheral NK cells. Spaan et al[] showed that viral load decline, as a consequence of DAAs therapy in patients with chronic hepatitis C infection, reduces serum levels of NK cell-stimulating cytokines and causes correcti […]


Perceptions of healthcare quality in Ghana: Does health insurance status matter?

PLoS One
PMCID: 5770037
PMID: 29338032
DOI: 10.1371/journal.pone.0190911

[…] ed to providers, schemes and community attributes play an important role at varying extents in household decision to voluntarily enrol and remain enrolled in insurance schemes. A systematic review by Spaan et al. [] of the impact of health insurance in Africa and Asia, concluded that there is a weakly positive effect of SHI and CBHI on quality of healthcare and that the effect of health insurance […]

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SPAAN institution(s)
G.N. Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India
SPAAN funding source(s)
Supported by Council of Scientific and Industrial Research under the New Millennium Indian Technology Leadership Initiative (NMITLI) program.

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