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|Alternative name||Subfamily Protein Architecture Labeling Engine|
|Restrictions to use||None|
|Data access||File download, Browse|
|User data submission||Not allowed|
- person_outline Aron Marchler-Bauer
Publication for Subfamily Protein Architecture Labeling Engine
Phyletic Distribution and Lineage Specific Domain Architectures of Archaeal Two Component Signal Transduction Systems
[…] The domain architectures of the archaeal RRs were manually checked against the CDD/SPARCLE and InterPro databases (, ). The RRs that contained, in addition to the REC domain, unassigned regions of ≥70 amino acid residues were marked as containing putative novel output domains (Table […]
Interdependence of Primary Metabolism and Xenobiotic Mitigation Characterizes the Proteome of Bjerkandera adusta during Wood Decomposition
[…] NCBI BLASTP (using a BLOSUM62 matrix), using only fungal sequences from the nonredundant protein database, with an E value cutoff of <1e−5. To characterize the proteins with unknown function, the CDD/SPARCLE domain analysis function () on NCBI was used to generate a map of any domains. Domain identifications on CDD had an E value cutoff of <1e−03, but each domain was also manually curated for accu […]
Cloning and Molecular Characterization of an Alpha Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi
[…] The predicted amino acid sequence of the putative glycosyl hydrolase from Hqrw_2071 was screened for the presence of functional domains using the NCBI’s CDD/SPARCLE Tools . In order to detect functional features with respect to protein structure, the COBALT program  was used to generate an anchored multiple sequence alignment (MSA) based on functional […]
What is the difference between the breakpoint graph and the de Bruijn graph?
[…] alternating between 3 colors, where the third color corresponds to repeated elements (see Figure ). Nurk and Pevzner  recently used this framework to develop a new comparative genome analysis tool SPArcle and applied it to analyzing multiple bacterial strains resulting from the "controlled evolution" experiments . SPArcle is based on SPAdes assembler and, in difference from Cortex, it uses id […]
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