SPAtest specifications


Unique identifier OMICS_16323
Name SPAtest
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 3.0
Computer skills Advanced
Version 3.0.0
Stability Stable
Maintained Yes


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  • person_outline Rounak Dey <>

Publication for SPAtest

SPAtest in publication

PMCID: 5595434
PMID: 28895531
DOI: 10.7554/eLife.25060.033

[…] controls, rare variants/icd9s or the presence of elevated distant relatedness. therefore, in addition to the glm, we also ran three other score based tests; (i) that use saddlepoint approximation (spatest) () to account for case:control imbalance; (ii) a linear mixed model (gcta) () to account for distant relatedness; and (iii) a test that incorporates a bias-reduction for small numbers […]

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SPAtest institution(s)
Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
SPAtest funding source(s)
This work was supported by grants R01 HG008773.

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