SPICE statistics

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Citations per year

Number of citations per year for the bioinformatics software tool SPICE

Tool usage distribution map

This map represents all the scientific publications referring to SPICE per scientific context
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Associated diseases

This word cloud represents SPICE usage per disease context

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SPICE specifications


Unique identifier OMICS_05645
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


No version available

Publication for SPICE

SPICE citations


Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV 1 infection and increased activity post vaccination

Nat Commun
PMCID: 5865158
PMID: 29572470
DOI: 10.1038/s41467-018-03618-w

[…] All flow data were analyzed in FlowJo LLC, Treestar Inc. (Ashland, OR), and then permutation tests were performed to determine statistical significance in comparison of pie charts generated in Spice software (Bethesda, MD). Volcano plots of the HTA data were generated using an affymetrix data table containing adjusted p-values and fold change pre-calculated by Affymetrix® TAC Software. Affy […]


Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility

PMCID: 5863314
PMID: 29707004
DOI: 10.1155/2018/8529104
call_split See protocol

[…] ctor of 150 in CYT for comparability, and subsamples of 5000 events were obtained randomly from the sample files before bh-SNE analysis.The analysis of viability and apoptosis was performed using the SPICE software [], which generated graphics illustrating the differences in the proportion of dead and apoptotic cells between the groups, and the statistical analysis was performed using the built-in […]


Functional, Antigen Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

Front Immunol
PMCID: 5839236
PMID: 29545791
DOI: 10.3389/fimmu.2018.00324
call_split See protocol

[…] Flow cytometry data was analyzed using FlowJo (Tree Star) versions v9.7 to v10.1r.1, Pestle version 1.8, and SPICE version 5.2–5.3 ().Threshold cycle (Ct) values were determined by the BioMark Real-time PCR Analysis software using linear derivative background correction and an amplification curve quality thr […]


Cytomegalovirus specific T cells are associated with immune senescence, but not with systemic inflammation, in people living with HIV

Sci Rep
PMCID: 5830877
PMID: 29491459
DOI: 10.1038/s41598-018-21347-4
call_split See protocol

[…] ), we analysed the magnitude of the total CMV-specific response (%CD8+ or %CD4+). Thus, each responding cell was calculated only once. Polyfunctionality visualization and analysis was performed using Spice Version 4.2.3 (Mario Roederer, ImmunoTechnology Section, VRC/NIAID/NIH) software. […]


Human Immunodeficiency Virus Type 1 Elite Controllers Maintain Low Co Expression of Inhibitory Receptors on CD4+ T Cells

Front Immunol
PMCID: 5786543
PMID: 29403500
DOI: 10.3389/fimmu.2018.00019
call_split See protocol

[…] or gating analysis, and statistical analysis was performed with GraphPad Prism 6.0. Analysis and graphical representation of cell surface inhibitory markers were conducted using data analysis program SPICE (version 5.35001) (). […]


Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial

Front Immunol
PMCID: 5702785
PMID: 29213269
DOI: 10.3389/fimmu.2017.01551
call_split See protocol

[…] cies. Pie charts were generated using relative frequencies with a threshold of 0.004% of the parent population. Data analysis was performed using FlowJo v10.1r1 (Treestar Inc., USA), Pestle v1.7, and Spice v5.3 (Mario Roederer, Vaccine Research Centre, NIAID, NIH, USA). […]

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SPICE institution(s)
Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA

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