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SPICE specifications


Unique identifier OMICS_05645
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


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Publication for SPICE

SPICE citations


Implication of Interleukin 12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine Preactivated Natural Killer Cells

Front Immunol
PMCID: 5911648
PMID: 29713323
DOI: 10.3389/fimmu.2018.00737

[…] phospho-stat5 (pstat5) abs. finally, cells were washed to remove unbound abs and further acquired in a facscanto ii flow cytometer. data were analyzed with flowjo software., graphpad prism v6.01 and spice v5.3 (vaccine research center, niaid) () softwares were used for graphical representation and statistical analysis. data were represented showing means ± sem. prior to statistical analyses, […]


Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV 1 infection and increased activity post vaccination

Nat Commun
PMCID: 5865158
PMID: 29572470
DOI: 10.1038/s41467-018-03618-w

[…] all flow data were analyzed in flowjo llc, treestar inc. (ashland, or), and then permutation tests were performed to determine statistical significance in comparison of pie charts generated in spice software (bethesda, md). volcano plots of the hta data were generated using an affymetrix data table containing adjusted p-values and fold change pre-calculated by affymetrix® tac software. […]


Functional, Antigen Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

Front Immunol
PMCID: 5839236
PMID: 29545791
DOI: 10.3389/fimmu.2018.00324

[…] for qpcr using a biomark hd system (fluidigm) according to the manufacturer’s protocol., flow cytometry data was analyzed using flowjo (tree star) versions v9.7 to v10.1r.1, pestle version 1.8, and spice version 5.2–5.3 ()., threshold cycle (ct) values were determined by the biomark real-time pcr analysis software using linear derivative background correction and an amplification curve quality […]


Human Immunodeficiency Virus Type 1 Elite Controllers Maintain Low Co Expression of Inhibitory Receptors on CD4+ T Cells

Front Immunol
PMCID: 5786543
PMID: 29403500
DOI: 10.3389/fimmu.2018.00019

[…] gating analysis, and statistical analysis was performed with graphpad prism 6.0. analysis and graphical representation of cell surface inhibitory markers were conducted using data analysis program spice (version 5.35001) ()., t cell exhaustion is a hallmark of hiv-1 disease. despite cd4+ t cells are critical for control of viral infections, less is known about their co-expression pattern […]


Detection of HIV 1 Specific Gastrointestinal Tissue Resident CD8+ T cells in Chronic Infection

PMCID: 5953759
PMID: 29139476
DOI: 10.1038/mi.2017.96

[…] significantly from the negative control. for responses deemed statistically significant, net responses were then calculated by subtracting negative control values from antigen-specific responses. spice software was used to visualize multifunctional t-cell populations. statistical analyses were performed with graphpad prism v.6 (graphpad software, san diego, ca) or spice. non-parametric […]


The Development of Plasmodium falciparum Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission

Front Immunol
PMCID: 5653696
PMID: 29097996
DOI: 10.3389/fimmu.2017.01329

[…] cd4 t cells were collected (iqr 98,310–144,000, minimum 10,000, maximum 197,000)., flow cytometry data were analyzed using flowjo software (tree star, san carlos, ca, usa) and pestle (version 1.7)/spice (version 5.3; m. roederer, vaccine research center, national institute of allergy and infectious diseases, national institute of health available at: http://exon.niaid.nih.gov (). color […]

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SPICE institution(s)
Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA

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