In silico tools have been developed to predict variants that may have an impact on pre-mRNA splicing. The major limitation of the application of these tools to basic research and clinical practice is the difficulty in interpreting the output. Most tools only predict potential…
Web app
G T A T C G C T A Human Splicing Finder Human Splicing Finder

HSF Human Splicing Finder

Predicts the effects of mutations on splicing signals or to identify splicing…

Predicts the effects of mutations on splicing signals or to identify splicing motifs in any human sequence. HSF contains all available matrices for auxiliary sequence prediction as well as new ones…

Web app
G T A T C G C T A IntSplice IntSplice

IntSplice

A support vector machine (SVM) model to predict aberrant splicing because of…

A support vector machine (SVM) model to predict aberrant splicing because of intronic SNVs (Int-SNVs) at positions from Int-50 to Int-3 (Int-50:Int-3). Following an effect-size analysis of each…

Web app
G T A T C G C T A SplicePort SplicePort

SplicePort

A versatile tool with two main functions. First, the user can perform accurate…

A versatile tool with two main functions. First, the user can perform accurate splice-site prediction on a sequence which they input to the tool, with the flexibility of exploring all the putative…

Web app
G T A T C G C T A SFmap SFmap

SFmap

A web server for predicting putative splicing factor binding sites in genomic…

A web server for predicting putative splicing factor binding sites in genomic data. SFmap implements the COS(WR) algorithm, which computes similarity scores for a given regulatory motif based on…

Web app
G T A T C G C T A AASsites AASsites

AASsites

An automated bioinformatics pipeline to analyse SNP containing DNA sequences…

An automated bioinformatics pipeline to analyse SNP containing DNA sequences mainly for finding SNPs which cause a change in the splicing pattern. AASsites first determines the position of the SNP.…

Web app
G T A T C G C T A CRYP-SKIP CRYP-SKIP

CRYP-SKIP

A web application for 5′ and 3′ splice site prediction. CRYP-SKIP takes up…

A web application for 5′ and 3′ splice site prediction. CRYP-SKIP takes up one or more mutated alleles, each consisting of one exon and flanking intronic sequences, and provides a list of…

Desktop app
Web app
G T A T C G C T A NetGene2 NetGene2

NetGene2

A service producing neural network predictions of splice sites in human, C.…

A service producing neural network predictions of splice sites in human, C. elegans and A. thaliana DNA. The prediction output for both server and mail server consist of the prediction for both…

Web app
G T A T C G C T A NetPlantGene NetPlantGene

NetPlantGene

Artificial neural networks have been combined with a rule based system to…

Artificial neural networks have been combined with a rule based system to predict intron splice sites in the dicot plant Arabidopsis thaliana. A two step prediction scheme, where a global prediction…

Web app
G T A T C G C T A SpliceView SpliceView

SpliceView

A web application for functional site analysis. SpliceView is based on four…

A web application for functional site analysis. SpliceView is based on four main assumptions: each variation of nucleotide composition makes a different contribution to the overall binding free…

Desktop app
Web app
G T A T C G C T A Splicing RegulatiOn… Splicing RegulatiOn Online GraphicaL Engine

SROOGLE Splicing RegulatiOn Online GraphicaL Engine

Makes splicing signal sequence and scoring data available to the biologist in…

Makes splicing signal sequence and scoring data available to the biologist in an integrated, visual, easily interpretable, and user-friendly format. SROOGLE's input consists of the sequence of…

Web app
G T A T C G C T A ESEfinder ESEfinder

ESEfinder

Allows for the identification of putative exonic splicing enhancers (ESEs) and…

Allows for the identification of putative exonic splicing enhancers (ESEs) and one of its most useful applications is the correct interpretation of the effects of disease-associated point mutations…

Desktop app
Web app
G T A T C G C T A GeneSplicer GeneSplicer

GeneSplicer

A flexible system for detecting splice sites in the genomic DNA of various…

A flexible system for detecting splice sites in the genomic DNA of various eukaryotes. The system has been trained and tested successfully on Plasmodium falciparum (malaria), Arabidopsis thaliana,…

Desktop app
Web app
G T A T C G C T A MaxEntScan MaxEntScan

MaxEntScan

Scores Human 5' splice sites. MaxEntScan is based on the approach for…

Scores Human 5' splice sites. MaxEntScan is based on the approach for modeling the sequences of short sequence motifs such as those involved in RNA splicing which simultaneously accounts for…

Web app
G T A T C G C T A NNSplice NNSplice

NNSplice

An improved splice site predictor for the genefinding program Genie. The…

An improved splice site predictor for the genefinding program Genie. The training and test sets of human and Drosophila melanogaster splice sites are available to the community for testing splice…

Web app
G T A T C G C T A Putative Exonic… Putative Exonic Splicing Enhancers/Silencers

PESX Putative Exonic Splicing Enhancers/Silencers

A computational approach to identify exonic splicing enhancers (ESEs) and…

A computational approach to identify exonic splicing enhancers (ESEs) and exonic splicing silencers (ESSs) associated with constitutively spliced exons. The large number of effective sequences…

Web app
G T A T C G C T A RESCUE-ESE RESCUE-ESE

RESCUE-ESE

Predicts which sequences have exonic splicing enhancer (ESE) activity by…

Predicts which sequences have exonic splicing enhancer (ESE) activity by statistical analysis of exon-intron and splice site composition. When large data sets of human gene sequences were used,…

Web app
G T A T C G C T A MutPred Splice MutPred Splice

MutPred Splice

A machine-learning approach for the identification of coding region…

A machine-learning approach for the identification of coding region substitutions that disrupt pre-mRNA splicing. Applying MutPred Splice to human disease-causing exonic mutations suggests that 16%…

Web app
G T A T C G C T A SKIPPY SKIPPY

SKIPPY

A tool for the detection of exonic variants that modulate splicing. SKIPPY…

A tool for the detection of exonic variants that modulate splicing. SKIPPY allows users to input a set of exonic variants to score them for a number of features (such as changes in splicing…

Web app
G T A T C G C T A Spliceman Spliceman

Spliceman

Predicts how likely distant mutations around annotated splice sites were to…

Predicts how likely distant mutations around annotated splice sites were to disrupt splicing. Spliceman takes a set of DNA sequences with point mutations and returns a ranked list to predict the…

Web app
G T A T C G C T A SplicePredictor SplicePredictor

SplicePredictor

Implements Bayesian models for splice site prediction. The predictions are…

Implements Bayesian models for splice site prediction. The predictions are implicitly based on the three variables of (i) degree of matching to the splice site consensus, (ii) local compositional…

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