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SPM specifications


Unique identifier OMICS_20649
Name SPM
Alternative names Statistical Parametric Mapping, SPM5, SPM12, SPM8
Software type Pipeline/Workflow
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Version 12
Stability Stable
Maintained Yes


No version available



  • person_outline SPM5 team

Additional information

http://www.fil.ion.ucl.ac.uk/spm/doc/spmbib.html http://www.fil.ion.ucl.ac.uk/spm/doc/

SPM citations


Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder

Sci Rep
PMCID: 5956073
PMID: 29769613
DOI: 10.1038/s41598-018-26042-y
call_split See protocol

[…] ghbors (26 voxels) in a voxel-wise way and the inclusive threshold for each voxel was set to P < 0.01. The following statistic analysis was conducted in SPM (http://www.fil.ion.ucl.ac.uk/spm/software/spm12/). A T test was applied to identify the differences between ADHD and control, and then a full factor model was built to test the main effect of the interaction effect of genotype and diagnosis, […]


Long term impacts of prenatal synthetic glucocorticoids exposure on functional brain correlates of cognitive monitoring in adolescence

Sci Rep
PMCID: 5955898
PMID: 29769646
DOI: 10.1038/s41598-018-26067-3
call_split See protocol

[…] were averaged and their absolute values were projected to the standard volumetric space in Brainstorm with a spatial resolution of 3 × 3 × 3 mm. The resulted volumetric signals were then imported to SPM8 (http://www.fil.ion.ucl.ac.uk/spm/) for statistical analysis. A full factorial ANOVA was conducted to compare the main effects of Condition (Go vs. NoGo), Group (PP/sGC vs. comparison group) and […]


The cholinergic contribution to the resting state functional network in non demented Parkinson’s disease

Sci Rep
PMCID: 5955917
PMID: 29769626
DOI: 10.1038/s41598-018-26075-3

[…] The analysis was done using Statistical Parametric Mapping software (SPM8, Wellcome Department of Imaging Neuroscience, London, UK, available at http://www.fil.ion.ucl.ac.uk/spm). Each structural MRI was bias-corrected, segmente […]


Neural predisposing factors of postoperative delirium in elderly patients with femoral neck fracture

Sci Rep
PMCID: 5954080
PMID: 29765105
DOI: 10.1038/s41598-018-26030-2

[…] To identify preoperative neural predisposing factors of delirium, second-level random effect analysis was conducted using SPM12 software to assess any differences in GM, FA, and ALFF between the DEL and No-DEL groups. All reported regional clusters survived at a corrected P < 0.05 threshold which corresponds to the famil […]


Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting state fMRI study

PMCID: 5957476
PMID: 29795981
DOI: 10.2147/NDT.S162325

[…] a preprocessing was conducted using the Data Processing and Analysis of Brain Imaging (DPABI) v2.1 (http://www.rfmri.org/dpabi) toolbox, which is based on the Statistical Parametric Mapping software (SPM12, http://www.fil.ion.ucl.ac.uk/spm/software/spm12/) for the MATLAB platform (The MathWorks Inc., Natick, MA, USA), using a method consistent with protocols of previously published studies. The pr […]


Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing remitting multiple sclerosis

PMCID: 5957478
DOI: 10.2147/NDT.S155478
call_split See protocol

[…] he inter-rater reliability was 92.8%.The high-resolution T1WI data were segmented into GM, WM, and cerebrospinal fluid using the new segmentation algorithm provided in Statistical Parametric Mapping (SPM12). The GM and WM probability images were then registered and warped into MNI space using the aforementioned DARTEL process. The brain parenchymal fraction (BPF) was then calculated as the ratio o […]


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SPM institution(s)
Wellcome Department of Cognitive Neurology, University College of London, London, UK

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