SPOCTOPUS statistics

info info

Citations per year

Number of citations per year for the bioinformatics software tool SPOCTOPUS

Tool usage distribution map

This map represents all the scientific publications referring to SPOCTOPUS per scientific context
info info

Associated diseases


Popular tool citations

chevron_left Secretome analysis chevron_right
Want to access the full stats & trends on this tool?


SPOCTOPUS specifications


Unique identifier OMICS_03896
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for SPOCTOPUS

SPOCTOPUS citations


A Novel Modeling in Mathematical Biology for Classification of Signal Peptides

Sci Rep
PMCID: 5773712
PMID: 29348418
DOI: 10.1038/s41598-018-19491-y

[…] Amino Acid Composition. Multiple classifications of protein are offered in. The perception of difference between signal sequence and its peptide chain is manipulated by predictors SS- and SP-indexes. SPOCTOPUS: a combined predictor of signal peptides and membrane protein topology based on neural networks, hidden Markov model (HMM) and dynamic programming algorithm is proposed in. Various researche […]


Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment*

PMCID: 5795391
PMID: 29141914
DOI: 10.1074/mcp.RA117.000400

[…] d supplemental Fig. S2A) was compiled by calculating the intersections of four data sets: “Predicted secreted proteins,” “SignalP predicted secreted proteins,” “Phobius predicted secreted proteins,” “SPOCTOPUS predicted secreted proteins” downloaded from the Human Protein Atlas:http://www.proteinatlas.org/search/protein_class:Predicted%20secreted%20proteinshttp://www.proteinatlas.org/search/protei […]


The bacterial Sec system is required for the organization and function of the MreB cytoskeleton

PLoS Genet
PMCID: 5629013
PMID: 28945742
DOI: 10.1371/journal.pgen.1007017

[…] and EnvC, which were shown to be inserted into the membrane and transported to the periplasm by the Sec system, respectively [,] and FtsK, which contains a potential signal sequence (as predicted by SPOCTOPUS []). However, our results point at MreB, which has been shown to be recruited to the forming septum in E. coli by FtsZ during the initial stages of cell division to enable Z-ring constrictio […]


Syp1 regulates the clathrin mediated and clathrin independent endocytosis of multiple cargo proteins through a novel sorting motif

Mol Biol Cell
PMCID: 5576906
PMID: 28701344
DOI: 10.1091/mbc.E15-10-0731

[…] annel.For cases in which protein topology is undetermined, motifs within Syp1 cargoes were assessed for residence in cytoplasmic regions of the protein using the membrane topology prediction software SPOCTOPUS (; http://octopus.cbr.su.se/). […]


Positive Allosteric Modulation of Insect Olfactory Receptor Function by ORco Agonists

PMCID: 5145856
PMID: 28018173
DOI: 10.3389/fncel.2016.00275
call_split See protocol

[…] . Predicted TM topologies for OR53 (TOPCONS) were 33–53, 68–83, 123–143, 174–194, 252–272, 281–301, 354–374. For OR9, six TM regions were predicted with most TOPCONS sub-methods used. The OCTOPUS and SPOCTOPUS sub-methods, however, predicted seven TM domains at 56–76, 87–107, 148–168, 192–222, 288–308, 319–339, 389–409 with the last one being predicted only by these two algorithms. […]


The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains

PLoS One
PMCID: 5104382
PMID: 27832149
DOI: 10.1371/journal.pone.0166274

[…] i.de/index.html; cleavage at T61), Signal BLAST (http://sigpep.services.came.sbg.ac.at/signalblast.html; cleavage at G58), Signal-CF (http://www.csbio.sjtu.edu.cn/bioinf/Signal-CF/; cleavage at A59), Spoctopus (http://octopus.cbr.su.se/; cleavage at G58), SPEPLip (http://gpcr.biocomp.unibo.it/cgi/predictors/spep/pred_spepcgi.cgi; cleavage at A59), Signal3L (http://www.csbio.sjtu.edu.cn/bioinf/Sign […]

Want to access the full list of citations?
SPOCTOPUS institution(s)
Department of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm, Sweden; Bioinformatics Center, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden


star_border star_border star_border star_border star_border
star star star star star

Be the first to review SPOCTOPUS