SPRINT specifications


Unique identifier OMICS_24042
Alternative name Scoring PRotein INTeractions
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data Some proteins sequences and PPIs.
Operating system Unix/Linux, Mac OS, Windows
Programming languages C++
License GNU General Public License version 3.0
Computer skills Advanced
Stability Stable
g++ compiler, OpenMP, boost
Maintained Yes




No version available


  • person_outline Lucian Ilie
  • person_outline Yiwei Li

Publication for Scoring PRotein INTeractions

SPRINT citations


Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition

Nat Methods
PMCID: 3882083
PMID: 24162924
DOI: 10.1038/nmeth.2702

[…] We were interested here not only in scoring protein interactions over a negative control, but importantly to systematically monitor interactome changes in pairs of samples (either sequence variants, or drug-treated samples; ). We electe […]


Topology and weights in a protein domain interaction network – a novel way to predict protein interactions

BMC Genomics
PMCID: 1523346
PMID: 16716232
DOI: 10.1186/1471-2164-7-122

[…] e distribution parameters by maximizing the likelihood of the data. Here, we applied the corresponding routines as of the Biopython package []. As a training set for true positives we choose 213 high scoring protein-interactions in yeast [] that are fully conserved in Plasmodium. In the same way, we selected 173 low scoring interactions as true negative training set. Applying a leave-one-out analy […]

SPRINT institution(s)
Department of Computer Science, The University of Western Ontario, London, ON, Canada
SPRINT funding source(s)
Supported by a Discovery Grant and a Research Tools and Instruments Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC).

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