SPRUCE specifications


Unique identifier OMICS_14281
Alternative name Somatic Phylogeny Reconstruction Using Combinatorial Enumeration
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data Confidence intervals and copy number mixing proportions for each character per sample.
Input format VAF
Output data Multi-state perfect phylogeny trees.
Operating system Unix/Linux
Programming languages C++
Computer skills Advanced
Stability Stable
CMake, Boost, LEMON, Graphviz
Maintained Yes



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  • person_outline Benjamin Raphael <>

Publication for Somatic Phylogeny Reconstruction Using Combinatorial Enumeration

SPRUCE institution(s)
Department of Computer Science and Center for Computational Molecular Biology, Brown University, Providence, RI, USA; Department of Computer Science, Carleton College, Northfield, MN, USA
SPRUCE funding source(s)
This work was supported by National Science Foundation (NSF) grant IIS- 1016648 and NIH grants R01HG005690, R01HG007069 and R01CA180776.

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