A comprehensive collection of carefully curated and classified residue- or segment-level data on the folding and/or stability proteins that have been previously investigated by solvent exchange-based measurements. Start2Fold entries contain (i) information on the proteins investigated and the underlying experimental procedures and (ii) the classification of the residues based on their exchange protection levels, also allowing for the instant visualization of the relevant residue groups on the 3D structures of the corresponding proteins. By providing a clear hierarchical framework for the easy sharing, comparison and (re-)interpretation of HDX data, Start2Fold intends to promote a better understanding of how the protein sequence encodes folding and structure as well as the development of new computational methods predicting protein folding and stability. The database is open to submissions; we encourage users to submit their folding and stability data using the template XML provided on the welcome page of the website.
Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Structural Biology Research Center (IB2), VIB, Brussels, Belgium; Interuniversity Institute of Bioinformatics in Brussels (IB2), ULB-VUB, Brussels, Belgium; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
Start2Fold funding source(s)
Brussels Institute for Research and Innovation (Innoviris) [BB2B 2010-1-12]; Research Foundation—Flanders (FWO) [Odysseus grant number G.0029.12]