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STITCH specifications


Unique identifier OMICS_03419
Alternative name Search Tool for Interactions of Chemicals
Restrictions to use None
Data access File download, Browse, Application programming interface
Version 5.0
Maintained Yes

Publications for Search Tool for Interactions of Chemicals

STITCH citations


Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

PMCID: 5854290
PMID: 29556515
DOI: 10.18632/oncoscience.395

[…] We first performed pathways enrichment analyses with either Search Tool for Interactions of Chemicals (STITCH) and Ingenuity Pathway Analysis (IPA) bioinformatic toolsets, using the differentially regulated kinases (from the phospho proteomic data) in H358-S c […]


A census of P. longum’s phytochemicals and their network pharmacological evaluation for identifying novel drug like molecules against various diseases, with a special focus on neurological disorders

PLoS One
PMCID: 5761900
PMID: 29320554
DOI: 10.1371/journal.pone.0191006

[…] PubChem and ChEMBL was derived using PubChem Sketcher v2.4 []. Compiled dataset was filtered to remove duplicate entries. Human proteins targeted by the phytochemicals were predicted from STITCH 5.0 (Search Tool for Interactions of Chemicals and proteins) [], BindingDB [], SwissTargetPrediction [] and PCIDB.The protein-chemical interaction reported in STITCH comes from the manually curated dataset […]


Predictive characterization of hypothetical proteins in Staphylococcus aureus NCTC 8325

PMCID: 5267966
PMID: 28149057
DOI: 10.6026/97320630012209

[…] raws from genomic context, high-throughput experiments, conserved co-expression, and previous PubMed literature []. STRING integrates interaction information on functional and physical relationships. Search Tool for Interactions of Chemicals (STITCH) is a database equal to STRING in its capacity to predict a hypothetical protein’s functional associates in a biological network []. STITCH integrate […]


Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery

Biomed Res Int
PMCID: 4633536
PMID: 26579539
DOI: 10.1155/2015/731292

[…] ensive drug information database that works based on bioinformatics and chemoinformatics data []. SuperTarget is a 2D drug screening and sequence comparison database for the extensive drug target []. Search Tool for Interactions of Chemicals (STITCH) and Ingenuity Pathway Analysis (IPA) are the searchable database that summarizes information from text mining, metabolic pathway, drug target relatio […]


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STITCH institution(s)
Institute of Molecular Life Sciences, University of Zurich and Swiss Institute of Bioinformatics, Zurich, Switzerland; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Molecular Medicine Partnership Unit, Heidelberg, Germany; Max-Delbrück-Centre for Molecular Medicine, Berlin, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
STITCH funding source(s)
Novo Nordisk Foundation [NNF14CC0001, in part]; European Molecular Biology Laboratory (EMBL, Heidelberg)

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