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STOCSY specifications


Unique identifier OMICS_24494
Alternative names Statistical TOtal Correlation SpectroscopY, iSTOCSY


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Publication for Statistical TOtal Correlation SpectroscopY

STOCSY citations


A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults

PMCID: 5915698
PMID: 29719871
DOI: 10.1128/mSystems.00044-18

[…] tra. Spectra were normalized using median fold change normalization to the median spectrum (). Combinations of data-driven strategies, such as SubseT optimization by reference matching (STORM) () and Statistical TOtal Correlation SpectroscopY (STOCSY) (), and analytical identification strategies were used to identify metabolites of interest from 1H-NMR data sets. Specifically, a catalogue of 1D 1H […]


GLP 1 receptor agonist ameliorates obesity induced chronic kidney injury via restoring renal metabolism homeostasis

PLoS One
PMCID: 5873987
PMID: 29590132
DOI: 10.1371/journal.pone.0193473

[…] CA-P (version 11.5, Umetrics, Sweden). OPLS-DA models were validated by a seven-fold cross validation method with a permutation test to avoid over-fitting. Statistical total correlation spectroscopy (STOCSY) analysis of metabolites was performed by MATLAB R2009a software (Mathworks, Natick, MA), and the OPLS-DA coefficient plot was generated with an in-house developed MATLAB script as previously d […]


Systemic Homeostasis in Metabolome, Ionome, and Microbiome of Wild Yellowfin Goby in Estuarine Ecosystem

Sci Rep
PMCID: 5823927
PMID: 29472553
DOI: 10.1038/s41598-018-20120-x
call_split See protocol

[…] NMR signals were annotated using 2D SENSI, STOCSY, SHY and other observed 2D NMR spectra as reported previously,. Detailed signal annotation is summarized in Table , Figures  and . […]


Application of kernel principal component analysis and computational machine learning to exploration of metabolites strongly associated with diet

Sci Rep
PMCID: 5821832
PMID: 29467421
DOI: 10.1038/s41598-018-20121-w

[…] es and tools, for example, include the human metabolome database, biological magnetic resonance data bank, 1H (13C) TOCCATA,, SpinAssign, SpinCouple, MetaboAnalyst, NMRShiftDB, MVAPACK, rNMR, BATMAN, statistical total correlation spectroscopy, fragment-assembly approach, and signal enhancement by spectral integration (SENSI) method.In the fields of NMR-based metabolomics, one key multivariate anal […]


Recommended strategies for spectral processing and post processing of 1D 1H NMR data of biofluids with a particular focus on urine

PMCID: 5809546
PMID: 29479299
DOI: 10.1007/s11306-018-1321-4

[…] or peak look-up tables (Martinez-Arranz et al. ). A variety of software packages for NMR statistical spectroscopy have been developed including, MetAssimulo (Muncey et al. ), Automics (Wang et al. ), Statistical total correlation spectroscopy (Cloarec et al. , ), and MVAPACK (Worley and Powers ).For relatively simple biofluids such as serum, plasma, cerebrospinal fluid (CSF), fecal water, juice, w […]


The utility of biomarkers in hepatocellular carcinoma: review of urine based 1H NMR studies – what the clinician needs to know

PMCID: 5708191
PMID: 29225478
DOI: 10.2147/IJGM.S150312

[…] to the difference between the variable of interest, used to help determine peaks that significantly differ, such as the classification of different patient groups or certain clinical measurements ().Statistical total correlation spectroscopy (STOCSY) is a technique developed by Cloarec et al to help determine the chemical structure of the molecule responsible for a peak of interest. Signals are i […]


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STOCSY institution(s)
Department of Chemistry, Frick Chemistry Laboratory, Princeton University , Princeton, NY, USA; NRM Group, Centro de Investigaciones en Bionanocencias, CIBION-CONICET, Polo Cientifico Tecnologico, Buenos Aires, Argentina

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