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Strain design software tools | Metabolic engineering data analysis

Strain design software tools | Metabolic engineering data analysis

Computational strain design protocols aim at the system-wide identification of intervention strategies for the enhanced production of biochemicals in microorganisms. Existing approaches relying solely on stoichiometry and rudimentary constraint-based regulation overlook the effects of metabolite concentrations and substrate-level enzyme regulation while identifying metabolic interventions.

Source text:
(Chowdhury et al., 2014) k-OptForce: integrating kinetics with flux balance analysis for strain design. PLoS Comput Biol.

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