An integrated platform that provides analysis, management and visualization tools for next-generation sequencing data. Strand NGS supports extensive workflows for alignment, RNA-seq, small RNA-seq, DNA-seq, Methyl-seq, MeDIP-seq and ChIP-seq experiments. Strand NGS supports an extensive workflow for the analysis and visualization of RNA-Seq data. The workflow includes standard differential expression analysis for different experimental conditions, as well as differential splicing analysis. It supports novel discovery including identifying novel genes and exons and novel splice junctions. It includes the ability to detect variants in the transcriptome, and the ability to detect gene fusion events. Further downstream analysis such as GO, pathway analysis, etc can be performed on the set of interesting genes. Strand NGS also supports an extensive workflow for the analysis and visualization of DNA-Seq data – such as from whole genome, whole exome or targeted resequencing experiments. The workflow includes the ability to detect variants (SNPs, MNPs and short InDels), annotate them with dbSNP, and identify the effect on transcripts of non-synonymous coding SNPs.