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Strand-seq which uses next-generation sequencing to assay sister chromatid inheritance patterns independently for each chromosome (Falconer et al., 2012) offers a comprehensive approach to test for non-random segregation. In addition Strand-seq enables studies on the deposition of chromatin marks in relation to DNA replication. This method is expected to help unify the field by testing previous claims of non-random segregation in an unbiased way in many model systems in vitro and in vivo. Source text: Falconer and Lansdorp, 2013).