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Streptococcus mutans | Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen

Presents the whole sequenced genome of Streptococcus mutans, the leading cause of dental caries (tooth decay) worldwide and the most cariogenic of all the oral streptococci. The genome of S. mutans UA159, a serotype c strain, has been completely sequenced and is composed of 2,030,936 base pairs. It contains 1,963 open reading frames (ORFs), 63% of which have been assigned putative functions. The genome analysis provides further insight into how S. mutans has adapted to surviving the oral environment through resource acquisition, defense against host factors, and use of gene products that maintain its niche against microbial competitors.

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Streptococcus mutans classification

  • Eubacteria

Streptococcus mutans specifications

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  • Joseph Ferretti <>


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Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, USA

Funding source(s)

This work was supported by Grant DE12489 from the National Institute of Dental and Craniofacial Research, National Institutes of Health.

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