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Structure-based B-cell epitope detection software tools | Immunoinformatics

In recent years, computational identification of immunogenic regions/segments in a given protein antigen has provided increasing assistance in guiding the experimental validation. Since the majority of the epitope area was dominated by discontinuous…
SAbPred
Web

SAbPred

A web server to make structure-based predictions for antibody engineering and…

A web server to make structure-based predictions for antibody engineering and design. It can be used to annotate the sequences of antibodies with different numbering schemes, automatically produce…

ElliPro
Web

ElliPro

Allows the prediction and visualization of antibody epitopes in a given protein…

Allows the prediction and visualization of antibody epitopes in a given protein sequence or structure. As ElliPro is based on the geometrical properties of protein structure and does not require…

SnugDock
Desktop

SnugDock

Performs multi-body docking by allowing simultaneous structural optimization of…

Performs multi-body docking by allowing simultaneous structural optimization of the relative orientations of antibody-antigen and inter-chain adjustments. SnugDock addresses the challenge toward…

LYRA
Web

LYRA LYmphocyte Receptor Automated modeling

Implements a complete and automated method for building of B- and T-cell…

Implements a complete and automated method for building of B- and T-cell receptor structural models starting from their amino acid sequence alone. LYRA is based on the canonical structure method and…

proABC
Web

proABC prediction of Antibody Contacts

A method to identify, on the basis of the antibody sequence alone, which…

A method to identify, on the basis of the antibody sequence alone, which residues of an antibody directly interact with its cognate antigen. The method, based on the random forest automatic learning…

BEpro
Web

BEpro

Uses a combination of amino-acid propensity scores and half sphere exposure…

Uses a combination of amino-acid propensity scores and half sphere exposure values at multiple distances to achieve state-of-the-art performance. BEpro achieves an area under the curve (AUC) of 75.4…

DiscoTope
Web

DiscoTope

Predicts discontinuous B cell epitopes from protein three dimensional…

Predicts discontinuous B cell epitopes from protein three dimensional structures. The method utilizes calculation of surface accessibility (estimated in terms of contact numbers) and a novel epitope…

Epitopia
Web

Epitopia

A web-based tool that aims to predict immunogenic regions in either a protein…

A web-based tool that aims to predict immunogenic regions in either a protein three-dimensional structure or a linear sequence. Epitopia implements a machine-learning algorithm that was trained to…

EPCES
Web

EPCES

Prediction of antigenic epitopes on protein surfaces by consensus scoring. The…

Prediction of antigenic epitopes on protein surfaces by consensus scoring. The energy function called EMPIRE (EMpirical Protein-InteRaction Energy), when coupled with a refinement strategy, is found…

Bpredictor
Desktop

Bpredictor

A method to identify the B-cell conformational epitopes from 3D structures by…

A method to identify the B-cell conformational epitopes from 3D structures by combining conventional features and new feature, and the random forest (RF) algorithm is used as the classification…

EPMeta
Desktop

EPMeta

A meta server for prediction of antigenic epitopes. EPMeta had a better…

A meta server for prediction of antigenic epitopes. EPMeta had a better performance than any single server - with an AUC of 0.638, significantly higher than PEPITO and Disctope (p-value < 0.05).

CE-KEG
Web

CE-KEG

A system which predicts conformational epitopes based on knowledge-based energy…

A system which predicts conformational epitopes based on knowledge-based energy and geometrical neighboring residue contents.

EPSVR
Web

EPSVR Epitopes Prediction with Support Vector Regression

Server application for discontinuous epitope prediction uses a Support Vector…

Server application for discontinuous epitope prediction uses a Support Vector Regression (SVR) method to integrate six scoring terms.

SEPPA
Web

SEPPA Spatial Epitope Prediction server for Protein Antigens

A server for conformational B-cell epitope prediction. With PDB structure as…

A server for conformational B-cell epitope prediction. With PDB structure as input, each residue in the query protein will be given a score according to not only its physical-chemical properties and…

CEP
Web

CEP

Provides a web interface to the conformational epitope prediction algorithm…

Provides a web interface to the conformational epitope prediction algorithm developed in-house. The algorithm, apart from predicting conformational epitopes, also predicts antigenic determinants and…

PEPOP
Web

PEPOP

Uses the 3D coordinates of a protein both to predict clusters of surface…

Uses the 3D coordinates of a protein both to predict clusters of surface accessible segments that might correspond to epitopes and to design peptides to be used to raise antibodies that target the…

LocaPep
Desktop

LocaPep

Allows users to predict potential epitopes on protein. LocaPep is a standalone…

Allows users to predict potential epitopes on protein. LocaPep is a standalone software, based on a new clusters algorithm, which allows prediction thanks to information provided by mapping peptides…

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