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Subfamily Protein Architecture Labeling Engine SPARCLE


A resource for the functional characterization and labeling of protein sequences that have been grouped by their characteristic conserved domain architecture. SPARCLE interface proposes to associate domain architectures with functional descriptions. Subfamily domain architectures as defined by the SPARCLE resource vary widely in their coverage and functional diversity. The resolution of this protein classification with respect to specific function depends directly on the availability of specific reagents in the NCBI's Conserved Domain Database (CDD) domain model collection.

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SPARCLE classification

SPARCLE specifications

Restrictions to use:
Data access:
File download, Browse
Community driven:
User data submission:
Not allowed

SPARCLE support


  • Aron Marchler-Bauer <>


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National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA

Funding source(s)

This work was supported by the Intramural Research Program of the National Library of Medicine at National Institutes of Health/DHHS.

Link to literature

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