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CaSPredictor / Caspase Substrate Predictor

A computer-based tool specific to caspase substrate prediction. CaSPredictor predicted successfully 81% (111/137) of the cleavage sites in experimentally verified caspase substrates not annotated in its internal data file. Its accuracy and confidence was estimated as 80% using ROC methodology. It is useful for preliminary screening of protein databanks for putative caspase targets and mapping potential cleavage sites and the strength of interactions in certain proteins experimentally demonstrated to be caspase substrates.