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Super-enhancers are genome regions that are large clusters of transcriptional enhancers (Hnisz et al., 2013). The term ‘super-enhancer’ was used for the first time by Chen et al. in 2004 (Chen et al., 2004). Super-enhancers differ from typical enhancers in size, transcription factor density and content, and the ability to activate transcription (Chapuy et al., 2013). Source text: Wei et al., 2015.