SuperComplex protocols

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SuperComplex specifications

Information


Unique identifier OMICS_11248
Name SuperComplex
Alternative name SCI-BN
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Stability Stable
Maintained Yes

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  • person_outline Ziv Bar-Joseph <>

Publication for SuperComplex

SuperComplex in pipelines

 (2)
2017
PMCID: 5359460
PMID: 28367336
DOI: 10.1155/2017/6468356

[…] the structure of jnk1 complexed with a small peptide belonging to jip scaffold protein [] was selected for the docking simulations. the structure of snap25 was extracted from the 20s supercomplex [] while the same jnk1 structure selected for the docking with syntaxin-1 was also used. the docking simulation was performed using haddock 2.2 [] program that is one […]

2017
PMCID: 5795388
PMID: 29222160
DOI: 10.1074/mcp.RA117.000470

[…] was performed using the tight ci-ciii2-civ supercomplex (pdb code 5j7z) and a complete ci structure (pdb code 5lnk), which were structurally aligned in pymol to generate a more complete ci-ciii2-civ supercomplex model. this model was also used to calculate alternative interaction spaces with the disvis web server (), assuming a maximum cross-linked cα–cα distance of 30 å., interaction networks […]


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SuperComplex in publications

 (486)
PMCID: 5928083
PMID: 29712914
DOI: 10.1038/s41467-018-04141-8

[…] oxidase without the intervention of any soluble electron carrier. besides the functional linkage of aciii with the caa3 oxygen reductase, the structural association of the two complexes into a supercomplex has also been proposed in r. marinus membranes based on biochemical and functional experiments. these observations agree with the fact that gene clusters encoding aciii are frequently […]

PMCID: 5908799
PMID: 29674655
DOI: 10.1038/s41467-018-03998-z

[…] 1, we next examined the integrity of oxphos complexes in macrophages using bn-page. bmdms of mache and macho mice expressed reduced levels of complexes i, ii, iv, and v, and formed an abnormal supercomplex between complexes iii and iv (supplementary fig. ). monitoring the oxygen consumption rate (ocr) in bmdms revealed that macrophages from macho mice exhibited reduced basal respiration, […]

PMCID: 5878687
PMID: 29610761
DOI: 10.15698/mic2018.04.625

[…] of impaired mitochondria during aging by autophagy, a quality control pathway that increases during aging . apart from a decrease in abundance of f1fo-atp-synthase dimers, a marked change of supercomplex amount s1 (i1iii2iv1) and s0 (i1iii2iv0) is observed during aging (fig. 1a). in cells of 6-days old cultures s1 predominates while this supercomplex is decreased in 16-days cultures. […]

PMCID: 5879135
PMID: 29632483
DOI: 10.3389/fnagi.2018.00079

[…] from a pd vps35 d620n carrier shows that this mutation leads to increased mitochondrial fission and functional deficits, likely through attenuated mitochondrial respiratory complex i and ii, and supercomplex assembly (). further, vps35 deficiency or d620n mutation increases mitochondrial fragmentation and da neuron death through mitochondrial e3 ubiquitin ligase 1 (mul1)-mediated degradation […]

PMCID: 5889907
PMID: 29765500
DOI: 10.1155/2018/5828120

[…] chain []. nd-1, a subunit of mitochondrial complex i, is encoded by mtdna. the lack of nd-1 causes mitochondrial dysfunction by disrupting the stability of complex i, complex iv, and the respiratory supercomplex []. atp, the energy source for basic cell functions and cellular repair and regeneration, is generated in the mitochondria via oxidative phosphorylation. decreased atp production […]


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SuperComplex institution(s)
School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
SuperComplex funding source(s)
This work was supported in part by National Science Foundation grants CAREER 0448453, EIA0225656, EIA0225636, CAREER CC044917, and National Institutes of Health grant LM07994-01.

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