Surface plasmon resonance data analysis software tools | Protein interactions
Surface plasmon resonance (SPR) is a powerful method for obtaining detailed molecular interaction parameters. Modern instrumentation with its increased throughput has enabled routine screening by SPR in hit-to-lead and lead optimization programs, and SPR has become a mainstream drug discovery technology. However, the processing and reporting of SPR data in drug discovery are typically performed manually, which is both time-consuming and tedious.
Allows users to simulate kinetic interaction curves. SPR-Simulation includes other functionalities assisting researchers to perform simulation of equilibrium sensorgrams. In summary, it enables the following simulations: single cycle kinetics, equilibrium kinetics, or multi cycle kinetics.
Assists users to simulate real-time interaction measurements. LigandTracer is a program that gives immediate feedback on the outcome, based on the users choice of concentration and incubation times. This tool is designed to be incorporated into university or industrial courses. With this software, each lesson explores a new aspect such as assay setup, kinetic theory and heterogeneous interactions.
Analyzes surface plasmon resonance analysis data. SPRTool permits users to examine large data sets in an automated fashion. Users can also import their own code. This method can perform standard analyses such as determination of equilibrium and kinetic constants. It also includes (i) the capability to compensate for the decrease in the sensitivity of the chip for equilibrium analysis and (ii) a method to determine kinetic constants using a non-iterative algorithm.
Provides a data evaluation tool for the measurement of enhanced sensorgrams from raw surface plasmon resonance (SPR) instrument data. EpiGrammer is able to improve sensitivity and specificity by readjusting the sensorgram. This software offers to users the possibility to import data files from standard SPR instruments, interactively calculate enhanced sensorgrams and re-export enhanced sensorgrams for downstream data evaluation such as kinetic evaluation.
Assists users to clean up biosensor data. Scrubber is a program able to perform data alignment and to remove artifacts prior to analysis. It allows researchers to write or read Biosensor files and includes options to compute mass transport rate.
Assists users for the utilization of surface plasmon resonance (SPR) systems in user-friendly way. Reichert4SPR System Software offers several features such as: a flexible and step-by-step control of the SPR system, or some drag and drop methods to set up multi-sample run tables or manual control of each component individually without constraints. It handles experimental method development, data acquisition and post-process analysis.
Assists researchers to evaluate, summarize and report results from real-time interaction experiments. TraceDrawer is a software that includes features to manage many types of time-resolved interaction data. Moreover, it contains others functionalities: creation of publishable figures, evaluation of affinity and EC50, comparison of results, collection of data, or evaluation of kinetics and competition.
Consists of an Excel file composed of computations used in biomolecular interaction analysis. BiaCalculations includes sections for calculations on conversions, equilibrium, immobilization, flow cell and diffusion. Moreover, it allows users to calculate dilution series and do some report-point transformations. A PDF file is also available for assisting researchers to exploit the Excel file.
A software tool designed for fast and efficient analysis of compound combination experiments. Dedicated calculation methods together with visualization methods such as heat maps and isobolograms enable assessment of combination effects, and the inherent automation, standardization, and flexibility of Genedata Screener provide excellent performance and streamlined workflows. Interactive calculation and visualization configuration combined with robust fitting produce better results in shorter time.
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