SUSPECTS specifications


Unique identifier OMICS_06532
Interface Web user interface
Restrictions to use None
Input data The region of interest and the training set.
Computer skills Basic
Version 28.3
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Euan Adie <>

Additional information

Publication for SUSPECTS

SUSPECTS in publications

PMCID: 4609397
PMID: 26504261
DOI: 10.1155/2015/828970

[…] (dbsnp137 and 1000 genomes project), or when they did not segregate with the eds-ht phenotype within the family., gene prioritization was performed with the web-based algorithms endeavour [], suspects [], g2d [], genedistiller [], and toppgene [], using a training set of 14 eds-associated genes (col1a1, col1a2, col5a1, col5a2, col3a1, tnxb, plod1, adamts2, chst14, b4galt7, slc39a13, […]

PMCID: 4457031
PMID: 26035869
DOI: 10.1242/dmm.018291

[…] as mean fold change relative to wild type. unpaired, two-tailed student's t-test was used to calculate p-values between the wild-type and mutant samples., we used three online algorithms comprising suspects (), toppgene () and endeavour () to prioritize the identified 337 degs. a list of 32 genes that are well-known to be associated with external ear malformation in human and mouse were used […]

PMCID: 3847089
PMID: 24312583
DOI: 10.1371/journal.pone.0081766

[…] etc for predicting the candidate gene., recently, several online tools have been developed for prioritizing candidate genes, which usually combine the different in silico approaches , . for example, suspects ranks genes by matching sequence features, go terms, interpro domains, and gene expression data. toppgene uses functional annotations, protein interaction networks to prioritize disease […]

PMCID: 3375301
PMID: 22719993
DOI: 10.1371/journal.pone.0038937

[…] a protein-protein interaction network to identify gene–disease associations. another system, endeavour , utilizes a set of known genes to create profiles which are then used to find matching genes. suspects prioritizes genes from a given chromosomal region, according to available gene and protein information, that might be implicated in a disease. since most of the available tools rely […]

PMCID: 3354662
PMID: 22654636
DOI: 10.1100/2012/842727

[…] profiles and linkage analysis, disease gene prediction [], and prospects [] that use basic sequence information to classify genes as likely or unlikely to be involved with the given disease, suspects [] an extended version of prospects that integrates annotation data from gene ontology (go) [], interpro [] and expression data. along this line of research is also medsim [] that uses go […]

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SUSPECTS institution(s)
Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh, UK

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