SUSPECTS specifications

Information


Unique identifier OMICS_06532
Name SUSPECTS
Interface Web user interface
Restrictions to use None
Input data The region of interest and the training set.
Computer skills Basic
Version 28.3
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Maintainer


  • person_outline Euan Adie <>

Additional information


http://www.cgem.ed.ac.uk/resources/suspects/help.shtml

Publication for SUSPECTS

SUSPECTS in publications

 (9)
PMCID: 4609397
PMID: 26504261
DOI: 10.1155/2015/828970

[…] (dbsnp137 and 1000 genomes project), or when they did not segregate with the eds-ht phenotype within the family., gene prioritization was performed with the web-based algorithms endeavour [], suspects [], g2d [], genedistiller [], and toppgene [], using a training set of 14 eds-associated genes (col1a1, col1a2, col5a1, col5a2, col3a1, tnxb, plod1, adamts2, chst14, b4galt7, slc39a13, […]

PMCID: 4457031
PMID: 26035869
DOI: 10.1242/dmm.018291

[…] as mean fold change relative to wild type. unpaired, two-tailed student's t-test was used to calculate p-values between the wild-type and mutant samples., we used three online algorithms comprising suspects (), toppgene () and endeavour () to prioritize the identified 337 degs. a list of 32 genes that are well-known to be associated with external ear malformation in human and mouse were used […]

PMCID: 3847089
PMID: 24312583
DOI: 10.1371/journal.pone.0081766

[…] etc for predicting the candidate gene., recently, several online tools have been developed for prioritizing candidate genes, which usually combine the different in silico approaches , . for example, suspects ranks genes by matching sequence features, go terms, interpro domains, and gene expression data. toppgene uses functional annotations, protein interaction networks to prioritize disease […]

PMCID: 3375301
PMID: 22719993
DOI: 10.1371/journal.pone.0038937

[…] a protein-protein interaction network to identify gene–disease associations. another system, endeavour , utilizes a set of known genes to create profiles which are then used to find matching genes. suspects prioritizes genes from a given chromosomal region, according to available gene and protein information, that might be implicated in a disease. since most of the available tools rely […]

PMCID: 3354662
PMID: 22654636
DOI: 10.1100/2012/842727

[…] profiles and linkage analysis, disease gene prediction [], and prospects [] that use basic sequence information to classify genes as likely or unlikely to be involved with the given disease, suspects [] an extended version of prospects that integrates annotation data from gene ontology (go) [], interpro [] and expression data. along this line of research is also medsim [] that uses go […]


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SUSPECTS institution(s)
Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh, UK

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